Protein-protein interactions are fundamental to the formation of intricate interaction networks
and the assembly of multisubunit protein complexes that represent the functional …

Proteins regulate biological processes by changing their structure or abundance to
accomplish a specific function. In response to a perturbation, protein structure may be …

This article is an introduction to the special issue of the journal PROTEINS, dedicated to the
tenth Critical Assessment of Structure Prediction (CASP) experiment to assess the state of …

Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

Targeted cancer therapies, which act on specific cancer-associated molecular targets, are
predominantly inhibitors of oncogenic kinases. While these drugs have achieved some …

Mass spectrometry-based methods have become increasingly important in structural biology—
in particular for large and dynamic, even heterogeneous assemblies of biomolecules. Native …

Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the
structure, function, and motion of proteins for students, faculty, and researchers at all levels …

Over the past two decades, mass spectrometry (MS) has emerged as a bone fide approach
for structural biology. MS can inform on all levels of protein organization, and enables …

NMR spectroscopy is a key method for studying the structure and dynamics of (large)
multidomain proteins and complexes in solution. It plays a unique role in integrated …

Covalent labeling (CL) in combination with mass spectrometry can be used as an analytical
tool to study and determine structural properties of protein-protein complexes. However …