Transcription factors (TFs) represent key biological players in diseases including cancer,
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …

Liquid–liquid phase separation (LLPS) is a novel principle for explaining the precise spatial
and temporal regulation in living cells. LLPS compartmentalizes proteins and nucleic acids …

CD8+ T cells that respond to chronic viral infections or cancer are characterized by the
expression of inhibitory receptors such as programmed cell death protein 1 (PD-1) and by …

Diffuse large B cell lymphoma (DLBCL) is the most common B cell non-Hodgkin lymphoma
and remains incurable in around 40% of patients. Efforts to sequence the coding genome …

Malignant transformation is characterized by dysregulation of diverse cellular processes that
have been the subject of detailed genetic, biochemical, and structural studies, but only …

The nucleus contains diverse phase-separated condensates that compartmentalize and
concentrate biomolecules with distinct physicochemical properties. Here, we investigated …

The mechanistic understanding of nascent RNAs in transcriptional control remains limited.
Here, by a high sensitivity method methylation-inscribed nascent transcripts sequencing …

INTRODUCTION Mammalian genes that play prominent roles in healthy and diseased
cellular states are often controlled by special DNA elements called super-enhancers (SEs) …

Phase-separated multi-molecular assemblies provide a general regulatory mechanism to
compartmentalize biochemical reactions within cells. We propose that a phase separation …

Epstein-Barr virus (EBV) is reportedly the first identified human tumor virus, and is closely
related to the occurrence and development of nasopharyngeal carcinoma (NPC), gastric …