Ang2 and Vegf Inhibitor Combinations

J Oliner, R Kendall, R Kumar - US Patent App. 12/223,003, 2009 - Google Patents
The following numbered paragraphs describe a few illustrative embodiments of the
invention that exemplify some of its aspects and features. They are not exhaustive in …

Synthesis and characterization of 4-methyl-1-(3-sulfopropyl) pyridinium hydrogen sulfate as a new ionic liquid immobilized on silica nanoparticles: A recyclable …

A Khalili, M Nasr-Esfahani… - Journal of Molecular …, 2018 - Elsevier
Methyl-1-(3-sulfopropyl) pyridinium hydrogen sulfate ([MSPP][HSO 4]) as a new acidic ionic
liquid was prepared in a quick and easy process, and characterized by some techniques …

Biologically relevant chemical space navigator: From patent and structure–activity relationship analysis to library acquisition and design

O Rabal, J Oyarzabal - Journal of chemical information and …, 2012 - ACS Publications
A new and versatile visualization tool, based on a descriptor accounting for ligand–receptor
interactions (LiRIf), is introduced for guiding medicinal chemists in analyzing the R-groups …

A convenient approach for the synthesis of various derivatives of pyrazolo[1,2-b]phthalazinediones in the presence of an efficient supported basic ionic liquid at …

F Hatami Sabour, M Nasr-Esfahani… - Journal of the Iranian …, 2018 - Springer
A convenient procedure has been described for one-pot synthesis of various pyrazolo [1, 2-
b] phthalazinediones at ambient temperature and solvent-free media. First, a novel …

Phthalazine derivatives as inhibitors of protein kinase

GL Araldi, M Ronsheim, M Ronsheim - US Patent 8,044,041, 2011 - Google Patents
The present invention relates to novel phthalazine derivatives and, more particularly, to
phthalazine derivatives of formula (III) that are useful as protein kinase inhibitors. The …

Fluorine containing diazines. Synthesis and properties

DM Volochnyuk, OO Grygorenko… - Fluorine in Heterocyclic …, 2014 - Springer
This review deals with general and significant developments in the area of chemistry of
fluorinated pyrimidine, pyrazine and pyridazine. Diazines bearing fluoro or α-fluoroalkyl …

Modulation of cell fates and activities by phthalazinediones

MO Henry, WS Lynn - US Patent 7,326,690, 2008 - Google Patents
Shall et al. West.......................... 514/310 Cole.......................... 514,289 aberrant redox states,
phthalazinediones enable cellular pro cesses essential for Survival and augment medical …

Phthalazine derivatives with angiogenesis inhibiting activity

G Bold, PW Manley - US Patent 7,399,761, 2008 - Google Patents
The invention relates to new phthalazine derivatives of for mula (I), wherein R and R: a) are
independently in each case a lower alkyl; b) together form a bridge of subformula (I) …

Modulation of cell fates and activities by phthalazinediones

M Henry, W Lynn - US Patent App. 11/699,853, 2007 - Google Patents
US20070142303A1 - Modulation of cell fates and activities by phthalazinediones - Google
Patents US20070142303A1 - Modulation of cell fates and activities by phthalazinediones …

Phthalazine derivatives for treating inflammatory diseases

G Bold, JD King, J Frei, R Heng, PW Manley… - US Patent …, 2008 - Google Patents
US7329660B2 - Phthalazine derivatives for treating inflammatory diseases - Google Patents
US7329660B2 - Phthalazine derivatives for treating inflammatory diseases - Google Patents …