[HTML][HTML] Functional and pathologic association of aminoacyl-tRNA synthetases with cancer

Y Sung, I Yoon, JM Han, S Kim - Experimental & molecular medicine, 2022 - nature.com
Although key tumorigenic and tumor-suppressive factors have been unveiled over the last
several decades, cancer remains the most life-threatening disease. Multiomic analyses of …

[HTML][HTML] The nuts and bolts of PIN auxin efflux carriers

M Zwiewka, V Bilanovičová, YW Seifu… - Frontiers in Plant …, 2019 - frontiersin.org
The plant-specific proteins named PIN-FORMED (PIN) efflux carriers facilitate the direction
of auxin flow and thus play a vital role in the establishment of local auxin maxima within …

[HTML][HTML] Selective neuronal vulnerability in Alzheimer's disease: a network-based analysis

JP Roussarie, V Yao, P Rodriguez-Rodriguez… - Neuron, 2020 - cell.com
A major obstacle to treating Alzheimer's disease (AD) is our lack of understanding of the
molecular mechanisms underlying selective neuronal vulnerability, a key characteristic of …

The Plant PTM Viewer, a central resource for exploring plant protein modifications

P Willems, A Horne, T Van Parys… - The Plant …, 2019 - Wiley Online Library
Post‐translational modifications (PTM s) of proteins are central in any kind of cellular
signaling. Modern mass spectrometry technologies enable comprehensive identification and …

[HTML][HTML] FOXO family isoforms

BF Santos, I Grenho, PJ Martel, BI Ferreira… - Cell Death & …, 2023 - nature.com
FOXO family of proteins are transcription factors involved in many physiological and
pathological processes including cellular homeostasis, stem cell maintenance, cancer …

qPTM: an updated database for PTM dynamics in human, mouse, rat and yeast

K Yu, Y Wang, Y Zheng, Z Liu, Q Zhang… - Nucleic Acids …, 2023 - academic.oup.com
Post-translational modifications (PTMs) are critical molecular mechanisms that regulate
protein functions temporally and spatially in various organisms. Since most PTMs are …

CPLM 4.0: an updated database with rich annotations for protein lysine modifications

W Zhang, X Tan, S Lin, Y Gou, C Han… - Nucleic Acids …, 2022 - academic.oup.com
Here, we reported the compendium of protein lysine modifications (CPLM 4.0, http://cplm.
biocuckoo. cn/), a data resource for various post-translational modifications (PTMs) …

Alterations in the global proteome and phosphoproteome in third generation EGFR TKI resistance reveal drug targets to circumvent resistance

X Zhang, TK Maity, KE Ross, Y Qi, CM Cultraro… - Cancer research, 2021 - AACR
Lung cancer is the leading cause of cancer mortality worldwide. The treatment of patients
with lung cancer harboring mutant EGFR with orally administered EGFR tyrosine kinase …

[HTML][HTML] Nucleolin: a cell portal for viruses, bacteria, and toxins

F Tonello, ML Massimino, C Peggion - Cellular and Molecular Life …, 2022 - Springer
The main localization of nucleolin is the nucleolus, but this protein is present in multiple
subcellular sites, and it is unconventionally secreted. On the cell surface, nucleolin acts as a …

EPSD: a well-annotated data resource of protein phosphorylation sites in eukaryotes

S Lin, C Wang, J Zhou, Y Shi, C Ruan… - Briefings in …, 2021 - academic.oup.com
As an important post-translational modification (PTM), protein phosphorylation is involved in
the regulation of almost all of biological processes in eukaryotes. Due to the rapid progress …