Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Tumours display an astonishing variation in the spatial distribution, composition and
activation state of immune cells, which impacts their progression and response to …

The transformative success of antibodies targeting the PD-1 (programmed death 1)/B7-H1
(B7 homolog 1) pathway (anti-PD therapy) has revolutionized cancer treatment. However …

Liver metastasis, the leading cause of colorectal cancer mortality, exhibits a highly
heterogeneous and suppressive immune microenvironment. Here, we sequenced 97 …

Most (if not all) tumors emerge and progress under a strong evolutionary pressure imposed
by trophic, metabolic, immunological, and therapeutic factors. The relative impact of these …

The demise of cells in various ways enables the body to clear unwanted cells. Studies over
the years revealed distinctive molecular mechanisms and functional consequences of …

Metabolic transformation is a hallmark of cancer and a critical target for cancer therapy.
Cancer metabolism and behaviour are regulated by cell-intrinsic factors as well as …

Altered metabolism is a hallmark of cancer, and the reprogramming of energy metabolism
has historically been considered a general phenomenon of tumors. It is well recognized that …

The metabolic challenges present in tumors attenuate the metabolic fitness and antitumor
activity of tumor-infiltrating T lymphocytes (TILs). However, it remains unclear whether …

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …