This article presents a personal and critical review of the history of the malate–aspartate
shuttle (MAS), starting in 1962 and ending in 2020. The MAS was initially proposed as a …

BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …

Suramin is 100 years old and is still being used to treat the first stage of acute human
sleeping sickness, caused by Trypanosoma brucei rhodesiense. Suramin is a …

Purines are synthesized de novo in 10 chemical steps that are catalyzed by six enzymes in
eukaryotes. Studies in vitro have provided little evidence of anticipated protein-protein …

The gross form changes undergone by trypanosomes when changing their environment are
accompanied by adaptive activation and repression of metabolic pathways and correlated …

The metabolic adaptation of eukaryotic cells to hypoxia involves increasing dependence
upon glycolytic adenosine triphosphate (ATP) production, an event with consequences for …

Recent work has shown that acidocalcisomes, which are electron-dense acidic organelles
rich in calcium and polyphosphate, are the only organelles that have been conserved during …

" Metabolic pathways are boring!" The attitude implicit in this assertion is not uncommon, and
probably arises because pathways are frequently considered to be uninteresting collections …

Abstract The African trypanosome, Trypanosoma brucei, has developed into a flexible and
robust experimental model for molecular and cellular parasitology, allowing us to better …

Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …