[HTML][HTML] Nanomedicines for the treatment of rheumatoid arthritis: State of art and potential therapeutic strategies

Q Wang, X Qin, J Fang, X Sun - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Increasing understanding of the pathogenesis of rheumatoid arthritis (RA) has remarkably
promoted the development of effective therapeutic regimens of RA. Nevertheless, the …

Recent advances in targeted drug delivery for treatment of osteoarthritis

S Mehta, T He, AG Bajpayee - Current opinion in rheumatology, 2021 - journals.lww.com
Recent years have witnessed significant increase in both fundamental and clinical studies
evaluating DDS for osteoarthritis. Steroid encapsulating polymeric microparticles for longer …

Microenvironment‐Activatable Probe for Precise NIR‐II Monitoring and Synergistic Immunotherapy in Rheumatoid Arthritis

Y Zhang, D Liu, W Chen, Y Tao, W Li… - Advanced Materials, 2024 - Wiley Online Library
Rheumatoid arthritis (RA) represents an insidious autoimmune inflammatory disorder that
severely lowers the life quality by progressively destructing joint functions and eventually …

Modification of mesenchymal stem cells for cartilage-targeted therapy

J Huang, Q Liu, J Xia, X Chen, J Xiong, L Yang… - Journal of translational …, 2022 - Springer
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the destruction
of the articular cartilage, sclerosis of the subchondral bone, and joint dysfunction. Its …

Phospholipase A2 inhibitor–loaded micellar nanoparticles attenuate inflammation and mitigate osteoarthritis progression

Y Wei, L Yan, L Luo, T Gui, B Jang… - Science …, 2021 - science.org
Treating osteoarthritis (OA) remains a major clinical challenge. Despite recent advances in
drug discovery and development, no disease-modifying drug for knee OA has emerged with …

[HTML][HTML] Strategies for heterologous expression, synthesis, and purification of animal venom toxins

E Rivera-de-Torre, C Rimbault, TP Jenkins… - … in bioengineering and …, 2022 - frontiersin.org
Animal venoms are complex mixtures containing peptides and proteins known as toxins,
which are responsible for the deleterious effect of envenomations. Across the animal …

Nanodevices for deep cartilage penetration

XL Xu, Y Xue, JY Ding, ZH Zhu, XC Wu, YJ Song… - Acta Biomaterialia, 2022 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease and is the main cause of chronic pain and
functional disability in adults. Articular cartilage is a hydrated soft tissue that is composed of …

Dexamethasone conjugates: Synthetic approaches and medical prospects

NV Dubashynskaya, AN Bokatyi, YA Skorik - Biomedicines, 2021 - mdpi.com
Dexamethasone (DEX) is the most commonly prescribed glucocorticoid (GC) and has a
wide spectrum of pharmacological activity. However, steroid drugs like DEX can have …

Biomaterial strategies for improved intra‐articular drug delivery

LM Mancipe Castro, AJ García… - Journal of Biomedical …, 2021 - Wiley Online Library
Osteoarthritis (OA) is a joint degenerative disease that has become one of the leading
causes of disability in the world. It is estimated that OA affects 50 million adults in the United …

Bioelectricity for drug delivery: the promise of cationic therapeutics

CC Young, A Vedadghavami, AG Bajpayee - Bioelectricity, 2020 - liebertpub.com
Biological systems overwhelmingly comprise charged entities generating electrical activity
that can have significant impact on biological structure and function. This intrinsic bio …