Puberty marks the end of childhood and is a period when individuals undergo physiological
and psychological changes to achieve sexual maturation and fertility. The hypothalamic …

Central precocious puberty results from the premature activation of the hypothalamic-
pituitary-gonadal axis. It mimics physiological pubertal development, although at an …

The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including
congenital and acquired causes that can be associated with structural or functional brain …

Pubertal timing is regulated by the complex interplay of genetic, environmental, nutritional
and epigenetic factors. Criteria for determining normal pubertal timing, and thus the …

MKRN3 mutations represent the most common genetic cause of central precocious puberty
(CPP) but associations between genotype and clinical features have not been extensively …

This review presents a comprehensive discussion of the clinical condition of delayed
puberty, a common presentation to the pediatric endocrinologist, which may present both …

BACKGROUND Puberty is a complex developmental event, controlled by sophisticated
regulatory networks that integrate peripheral and internal cues and impinge at the brain …

The pubertal development onset is controlled by a network of genes that regulate the
gonadotropin releasing hormone (GnRH) pulsatile release and the subsequent increase of …

Context and objective Idiopathic central precocious puberty (iCPP) is defined as early
activation of the hypothalamic–pituitary–gonadal axis in the absence of identifiable central …

Activation of the hypothalamic-pituitary-gonadal (HPG) axis happens in 3 phases during life.
The first phase is during fetal life and is only separated from the second phase, called …