On the molecular mechanisms regulating animal cell size homeostasis

E Zatulovskiy, JM Skotheim - Trends in Genetics, 2020 - cell.com
Cell size is fundamental to cell physiology because it sets the scale of intracellular geometry,
organelles, and biosynthetic processes. In animal cells, size homeostasis is controlled …

[图书][B] Stochastic processes in cell biology

PC Bressloff - 2014 - Springer
One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Cell size control and gene expression homeostasis in single-cells

CA Vargas-Garcia, KR Ghusinga, A Singh - Current opinion in systems …, 2018 - Elsevier
Growth of a cell and its subsequent division into daughters is a fundamental aspect of all
cellular living systems. During these processes, how do individual cells correct size …

Cell size distribution of lineage data: analytic results and parameter inference

C Jia, A Singh, R Grima - Iscience, 2021 - cell.com
Recent advances in single-cell technologies have enabled time-resolved measurements of
the cell size over several cell cycles. These data encode information on how cells correct …

Cell size control driven by the circadian clock and environment in cyanobacteria

BMC Martins, AK Tooke, P Thomas… - Proceedings of the …, 2018 - National Acad Sciences
How cells maintain their size has been extensively studied under constant conditions. In the
wild, however, cells rarely experience constant environments. Here, we examine how the 24 …

Mechanisms of cell size regulation in slow-growing Escherichia coli cells: discriminating models beyond the adder

C Nieto, CA Vargas-García, JM Pedraza… - npj Systems Biology and …, 2024 - nature.com
Under ideal conditions, Escherichia coli cells divide after adding a fixed cell size, a strategy
known as the adder. This concept applies to various microbes and is often explained as the …

Mycobacteria modify their cell size control under sub-optimal carbon sources

M Priestman, P Thomas, BD Robertson… - Frontiers in cell and …, 2017 - frontiersin.org
The decision to divide is the most important one that any cell must make. Recent single cell
studies suggest that most bacteria follow an “adder” model of cell size control, incorporating …

Division rate, cell size and proteome allocation: impact on gene expression noise and implications for the dynamics of genetic circuits

F Bertaux, S Marguerat… - Royal Society open …, 2018 - royalsocietypublishing.org
The cell division rate, size and gene expression programmes change in response to
external conditions. These global changes impact on average concentrations of biomolecule …

PDE models of adder mechanisms in cellular proliferation

M Xia, CD Greenman, T Chou - SIAM journal on applied mathematics, 2020 - SIAM
Cell division is a process that involves many biochemical steps and complex biophysical
mechanisms. To simplify the understanding of what triggers cell division, three basic models …

Analysis of cell size homeostasis at the single-cell and population level

P Thomas - Frontiers in Physics, 2018 - frontiersin.org
Growth pervades all areas of life from single cells to cell populations to tissues. Cell size
often fluctuates significantly from cell to cell and from generation to generation. Here we …