Deletions and duplications of chromosomal segments (copy number variants, CNVs) are a
major source of variation between individual humans and are an underlying factor in human …

Orderly replication of DNA is a prerequisite to the faithful segregation of the chromosomes
before cell division. These processes occur in an environment where the natural order of …

Genome rearrangements can take place by a process known as replication slippage or copy-
choice recombination. The slippage occurs between repeated sequences in both …

Rearrangements between tandem sequence homologies of various lengths are a major
source of genomic change and can be deleterious to the organism. These rearrangements …

Replication arrest leads to the occurrence of DNA double-stranded breaks (DSB). We
studied the mechanism of DSB formation by direct measure of the amount of in vivo linear …

DNA synthesis is an accurate and very processive phenomenon; nevertheless, replication
fork progression on chromosomes can be impeded by DNA lesions, DNA secondary …

The roles of UvrD and Rep DNA helicases of Escherichia coli are not yet fully understood. In
particular, the reason for rep uvrD double mutant lethality remains obscure. We reported …

Replication arrests are associated with genome rearrangements, which result from either
homologous or non-homologous recombination. Interestingly, proteins involved in …

Bacterial replicases are complex, tripartite replicative machines. They contain a polymerase,
polymerase III (Pol III), a β2 processivity factor, and a DnaX complex ATPase that loads β2 …

The inactivation of a replication protein causes the disassembly of the replication machinery
and creates a need for replication reactivation. In several replication mutants, restart occurs …