Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …

The automatism of cardiac pacemaker cells, which is tuned, is regulated by the autonomic
nervous system (ANS) and multiple endocrine and paracrine factors, including …

Cold thermoreceptors have been described in different territories of the vagus nerve.
Application of cold temperature to these visceral afferents can evoke major protective …

We have shown that the gene SCN10A encoding the sodium channel Nav1. 8 is a
susceptibility factor for heart block and serious ventricular arrhythmia. Since Nav1. 8 is …

Recent study from our laboratory has indicated that microinjection of glutamate into the
nucleus tractus solitarius (NTS) facilitates the cardiac-somatic reflex induced by pericardial …

INTRODUCTION: Inflammation during systemic lipopolysaccharide (LPS) seems to be
modulated by the CNS via afferent and efferent vagal pathways. We hypothesized that …

In many instances, the perception of pain is disproportionate to the strength of the algesic
stimulus. Excessive or inadequate pain sensation is frequently observed in cardiovascular …

Emerging evidence indicates a nociceptive role of vagal afferents. A distinct oesophageal
innervation in the rat, with muscular and mucosal afferents travelling predominantly in the …

Despite the contribution of nodose ganglia neurons to the innervation of the heart being the
subject of several studies, specific neuronal subpopulations innervating the four different …

Philosophical'thought experiments' invoking inverted spectra, zombies, et cetera suggest
that conscious sensations have no function, and psychological studies finding no correlation …