Several studies implicate dysregulation of the ADAMTS-13/VWF axis as playing a major role
in vaso-occlusive events (VOE) in SCD. Another highlight is reducing iron overload, which …

Heme is essential for a variety of proteins involved in vital physiological functions in the
body, such as oxygen transport, drug metabolism, biosynthesis of steroids, signal …

Imaging and characterizing the dynamics of cellular adhesion in blood samples is of
fundamental importance in understanding biological function. In vitro microscopy methods …

Autophagy plays a crucial role in maintaining endothelial cell homeostasis through the
turnover of intracellular components during stress conditions in a lysosomal-dependent …

Red blood cell-derived extracellular vesicles (RBC EVs) are small, spherical fragments
released from red blood cells. These vesicles, similar to EVs derived from other cell types …

Could the phenomenon of catch bonding—force-strengthened cellular adhesion—play a
role in sickle cell disease, where abnormal red blood cell (RBC) adhesion obstructs blood …

In this paper, An Ran et al. 1 report on keystone findings in sickle cell disease (SCD)
pathophysiology. The authors explored the adhesion processes caused by human sickle …

Thromboembolic events are a significant clinical concern in thalassemia and
hemoglobinopathies, highlighting the need for new strategies to treat and detect these …

This review provides a current update about recent discoveries on heme/iron-activated
macrophages in SCD, shedding light on their critical role in disease pathophysiology …

Emerging functional microfluidic assays for the study of thr... : Current Opinion in
Hematology Emerging functional microfluidic assays for the study of thromboinflammation in …