Hypoxia is one of the fundamental biological phenomena that are intricately associated with
the development and aggressiveness of a variety of solid tumors. Hypoxia-inducible factors …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high
incidence of distant metastasis and recurrence. Cancer stem cells (CSCs), which are …

Background Cancer stem cells (CSCs) can proliferate and self-renew extensively due to
their ability to express anti-apoptotic and drug resistant proteins, thus sustaining tumor …

Activation of Notch-1 is known to be associated with the development and progression of
human malignancies including pancreatic cancer. Emerging evidence suggest that the …

Activation of the sonic hedgehog (SHh) pathway is required for the growth of numerous
tissues and organs and recent evidence indicates that this pathway is often recruited to …

FoxM1 is known to play important role in the development and progression of many
malignancies including pancreatic cancer. Studies have shown that the acquisition of …

Pancreatic cancer is an exceptionally aggressive disease in great need of more effective
therapeutic options. Epithelial–mesenchymal transition (EMT) plays a key role in cancer …

Background The existence of cancer stem cells (CSCs) or cancer stem-like cells in a tumor
mass is believed to be responsible for tumor recurrence because of their intrinsic and …

Sulforaphane (SFN), a component of dietary cruciferous vegetables has been characterized
for its anti-proliferative properties. We have recently demonstrated that pancreatic CSCs …

According to the cancer stem cell hypothesis, the aggressive growth and early metastasis of
cancer may arise through dysregulation of self-renewal of stem cells. The objectives of this …