Thirty years ago, one of the first types of CD4+ T regulatory cells was discovered and named
T regulatory type 1 (Tr1) cells. Tr1 cells represent a distinct population of T cells, which are …

Abstract Interleukin (IL)-10 is an essential anti-inflammatory cytokine and functions as a
negative regulator of immune responses to microbial antigens. IL-10 is particularly important …

Abstract Interleukin (IL)-10 is an important immunoregulatory cytokine and an understanding
of how IL-10 expression is controlled is critical in the design of immune intervention …

Abstract Interleukin (IL)-10 is an essential anti-inflammatory cytokine that plays important
roles as a negative regulator of immune responses to microbial antigens. Loss of IL-10 …

The mechanisms controlling CD4+ T cell switching from an effector to an anti-inflammatory
(IL-10+) phenotype play an important role in the persistence of chronic inflammatory …

CD4+ T-cells have been shown to play a central role in immune control of infection with
Plasmodium parasites. At the erythrocytic stage of infection, IFN-γ production by CD4+ T …

In light of an escalating prevalence of allergic disorders, it is crucial to fully comprehend their
pathophysiology and etiology. Such knowledge would play a pivotal role in the search for …

Mucosal associated invariant T (MAIT) cells are abundant unconventional T cells that can be
stimulated either via their TCR or by innate cytokines. The MAIT cell TCR recognises a …

Mesenchymal stem cells (MSCs) possess immunomodulatory properties and have potential,
however, there have been conflicting reports regarding their effects in rheumatoid arthritis …

The immune system is essential for host defense against pathogen infections; however
dysregulated immune response may lead to inflammatory or autoimmune diseases …