Autophagy is a lysosome-dependent cellular degradation program that responds to a variety
of environmental and cellular stresses. It is an evolutionarily well-conserved and essential …

Autophagy is a highly conserved process and is essential for the maintenance of cellular
homeostasis. Autophagy occurs at a basal level in all cells, but it can be up-regulated during …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Autophagy is a catabolic pathway required for the recycling of cytoplasmic materials. To
define the mechanisms underlying autophagy it is critical to quantitatively characterize the …

Introduction: Obesity and type 2 diabetes are growing health problems worldwide. The three
principal diabetogenic factors are adiposity, insulin resistance in skeletal muscle, and …

Sestrins are stress-inducible metabolic regulators that suppress a wide range of age-and
obesity-associated pathologies, many of which are due to mTORC1 overactivation. Upon …

Autophagy pathways are involved in the pathogenesis of some obesity related health
problems. As obesity is a nutrient sufficiency condition, autophagy process can be altered in …

Dysregulation of the balance between cell proliferation and cell death is a central feature of
malignances. Death-associated protein kinase 3 (DAPK3) regulates programmed cell death …

Significance: Alterations in adipose tissue function have profound consequences on whole
body energy homeostasis because this tissue is central for fat accumulation, energy …

Objective Normal adipose tissue growth and function is critical to maintaining metabolic
homeostasis and its excess (eg obesity) or absence (eg lipodystrophy) is associated with …