Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy

L Yang, Z Chu, M Liu, Q Zou, J Li, Q Liu… - Journal of hematology & …, 2023 - Springer
Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …

Supplying the trip to antibody production—nutrients, signaling, and the programming of cellular metabolism in the mature B lineage

MR Boothby, SK Brookens, AL Raybuck… - Cellular & Molecular …, 2022 - nature.com
The COVID pandemic has refreshed and expanded recognition of the vital role that
sustained antibody (Ab) secretion plays in our immune defenses against microbes and of …

SNORD88C guided 2′-O-methylation of 28S rRNA regulates SCD1 translation to inhibit autophagy and promote growth and metastasis in non-small cell lung …

K Wang, S Wang, Y Zhang, L Xie, X Song… - Cell Death & …, 2023 - nature.com
Small nucleolar RNAs (snoRNAs) have been shown to play critical regulatory roles in
cancer development. SNORD88C, which located at the intronic region of C19orf48 in …

Lipid metabolism associated crosstalk: the bidirectional interaction between cancer cells and immune/stromal cells within the tumor microenvironment for prognostic …

Z Lin, G Hua, X Hu - Cancer Cell International, 2024 - Springer
Cancer is closely related to lipid metabolism, with the tumor microenvironment (TME)
containing numerous lipid metabolic interactions. Cancer cells can bidirectionally interact …

Fatty acid metabolism in adaptive immunity

X Zhou, X Zhu, H Zeng - The FEBS journal, 2023 - Wiley Online Library
Fatty acids (FAs) not only are a key component of cellular membrane structure, but also have
diverse functions in biological processes. Recent years have seen great advances in …

Obesity dysregulates the immune response to influenza infection and vaccination through metabolic and inflammatory mechanisms

SR Shaikh, NJ MacIver, MA Beck - Annual review of nutrition, 2022 - annualreviews.org
The COVID-19 pandemic demonstrates that obesity alone, independent of comorbidities, is
a significant risk factor for severe outcomes from infection. This susceptibility mirrors a …

Obesity, dietary fats, and gastrointestinal cancer risk-potential mechanisms relating to lipid metabolism and inflammation

KAJ Mitchelson, F O'Connell, J O'Sullivan, HM Roche - Metabolites, 2024 - mdpi.com
Obesity is a major driving factor in the incidence, progression, and poor treatment response
in gastrointestinal cancers. Herein, we conducted a comprehensive analysis of the impact of …

Knockout of stearoyl-CoA desaturase 1 decreased milk fat and unsaturated fatty acid contents of the goat model generated by CRISPR/Cas9

H Tian, H Niu, J Luo, W Yao, X Chen, J Wu… - Journal of Agricultural …, 2022 - ACS Publications
Goat milk contains a rich source of nutrients, especially unsaturated fatty acids. However, the
regulatory mechanism of milk fat and fatty acid synthesis remains unclear. Stearoyl-CoA …

[HTML][HTML] Immunomodulatory effect of camellia oil (Camellia oleifera Abel.) on CD19+ B cells enrichment and IL-10 production in BALB/c mice

CY Lin, SY Chen, WT Lee, GC Yen - Journal of Functional Foods, 2022 - Elsevier
Abstract Camellia oil (Camellia oleifera Abel.) has anti-inflammatory, antioxidant, and
microbiota-modulating abilities, but little is known about the effects of camellia oil on immune …

Lipid metabolism in B cell biology

R Peeters, J Jellusova - Molecular Oncology, 2024 - Wiley Online Library
In recent years, the field of immunometabolism has solidified its position as a prominent area
of investigation within the realm of immunological research. An expanding body of scientific …