Healthy aging and the blood–brain barrier

WA Banks, MJ Reed, AF Logsdon, EM Rhea… - Nature aging, 2021 - nature.com
The blood–brain barrier (BBB) protects the central nervous system (CNS) from unregulated
exposure to the blood and its contents. The BBB also controls the blood-to-brain and brain …

Polyunsaturated fatty acids and their metabolites in brain function and disease

RP Bazinet, S Layé - Nature reviews neuroscience, 2014 - nature.com
The brain is highly enriched with fatty acids. These include the polyunsaturated fatty acids
(PUFAs) arachidonic acid and docosahexaenoic acid, which are largely esterified to the …

[HTML][HTML] Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease

AR Nelson, MD Sweeney, AP Sagare… - Biochimica et Biophysica …, 2016 - Elsevier
Vascular insults can initiate a cascade of molecular events leading to neurodegeneration,
cognitive impairment, and dementia. Here, we review the cellular and molecular …

[HTML][HTML] Docosahexaenoic acid and cognition throughout the lifespan

MJ Weiser, CM Butt, MH Mohajeri - Nutrients, 2016 - mdpi.com
Docosahexaenoic acid (DHA) is the predominant omega-3 (n-3) polyunsaturated fatty acid
(PUFA) found in the brain and can affect neurological function by modulating signal …

Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer's disease

G Verdile, KN Keane, VF Cruzat, S Medic… - Mediators of …, 2015 - Wiley Online Library
Type 2 diabetes (T2DM), Alzheimer's disease (AD), and insulin resistance are age‐related
conditions and increased prevalence is of public concern. Recent research has provided …

Docosahexaenoic acid (DHA): An essential nutrient and a nutraceutical for brain health and diseases

GY Sun, A Simonyi, KL Fritsche, DY Chuang… - … and Essential Fatty …, 2018 - Elsevier
Docosahexaenoic acid (DHA), a polyunsaturated fatty acid (PUFA) enriched in
phospholipids in the brain and retina, is known to play multi-functional roles in brain health …

[HTML][HTML] Omega-3 fatty acids and neurodegenerative diseases: new evidence in clinical trials

R Avallone, G Vitale, M Bertolotti - International journal of molecular …, 2019 - mdpi.com
A nutritional approach could be a promising strategy to prevent or slow the progression of
neurodegenerative diseases such as Parkinson's and Alzheimer's disease, since there is no …

[HTML][HTML] APOE alleles and diet in brain aging and Alzheimer's disease

HN Yassine, CE Finch - Frontiers in aging neuroscience, 2020 - frontiersin.org
The APOE gene alleles modify human aging and the response to the diet at many levels
with diverse pleotropic effects from gut to brain. To understand interactions of APOE isoforms …

[HTML][HTML] Lipid transport and metabolism at the blood-brain interface: Implications in health and disease

F Pifferi, B Laurent, M Plourde - Frontiers in physiology, 2021 - frontiersin.org
Many prospective studies have shown that a diet enriched in omega-3 polyunsaturated fatty
acids (n-3 PUFAs) can improve cognitive function during normal aging and prevent the …

[HTML][HTML] Brain docosahexaenoic acid uptake and metabolism

RJS Lacombe, R Chouinard-Watkins… - Molecular Aspects of …, 2018 - Elsevier
Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the
brain where it serves to regulate several important processes and, in addition, serves as a …