Recent technical developments in ASL: a review of the state of the art

L Hernandez‐Garcia… - Magnetic resonance …, 2022 - Wiley Online Library
This review article provides an overview of a range of recent technical developments in
advanced arterial spin labeling (ASL) methods that have been developed or adopted by the …

[HTML][HTML] Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: A technical review in the era of PET/MRI

AP Fan, H An, F Moradi, J Rosenberg, Y Ishii, T Nariai… - Neuroimage, 2020 - Elsevier
Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO 2) are
key cerebral physiological parameters to identify at-risk cerebrovascular patients and …

Recent progress in ASL

L Hernandez-Garcia, A Lahiri, J Schollenberger - Neuroimage, 2019 - Elsevier
This article aims to provide the reader with an overview of recent developments in Arterial
Spin Labeling (ASL) MRI techniques. A great deal of progress has been made in recent …

Cerebral oxygen extraction fraction MRI: Techniques and applications

D Jiang, H Lu - Magnetic resonance in medicine, 2022 - Wiley Online Library
The human brain constitutes 2% of the body's total mass but uses 20% of the oxygen. The
rate of the brain's oxygen utilization can be derived from a knowledge of cerebral blood flow …

[HTML][HTML] An investigation of cerebral oxygen utilization, blood flow and cognition in healthy aging

SJ Catchlove, H Macpherson, ME Hughes, Y Chen… - PLoS …, 2018 - journals.plos.org
Background Understanding how vascular and metabolic factors impact on cognitive function
is essential to develop efficient therapies to prevent and treat cognitive losses in older age …

MRI-based methods for quantification of the cerebral metabolic rate of oxygen

ZB Rodgers, JA Detre… - Journal of Cerebral Blood …, 2016 - journals.sagepub.com
The brain depends almost entirely on oxidative metabolism to meet its significant energy
requirements. As such, the cerebral metabolic rate of oxygen (CMRO2) represents a key …

Validation of T2‐based oxygen extraction fraction measurement with 15O positron emission tomography

D Jiang, S Deng, CG Franklin, M O'Boyle… - Magnetic resonance …, 2021 - Wiley Online Library
Purpose To evaluate the accuracy of T2‐based whole‐brain oxygen extraction fraction
(OEF) estimation by comparing it with gold standard 15O‐PET measurements. Methods …

Brain oxygen extraction is differentially altered by Alzheimer's and vascular diseases

D Jiang, Z Lin, P Liu, S Sur, C Xu… - Journal of Magnetic …, 2020 - Wiley Online Library
Background Alzheimer's disease and vascular cognitive impairment (VCI), as well as their
concurrence, represent the most common types of cognitive dysfunction. Treatment …

Oxygen metabolism in acute ischemic stroke

W Lin, WJ Powers - Journal of Cerebral Blood Flow & …, 2018 - journals.sagepub.com
Gaining insights into brain oxygen metabolism has been one of the key areas of research in
neurosciences. Extensive efforts have been devoted to developing approaches capable of …

Mapping oxidative metabolism in the human brain with calibrated fMRI in health and disease

JJ Chen, B Uthayakumar… - Journal of Cerebral Blood …, 2022 - journals.sagepub.com
Conventional functional MRI (fMRI) with blood-oxygenation level dependent (BOLD)
contrast is an important tool for mapping human brain activity non-invasively. Recent interest …