Epilepsy is a chronic neurological disease characterized by an enduring propensity for
generation of seizures. The pathogenic processes of seizure generation and recurrence are …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …

The world's population aging progression renders age‐related neurodegenerative diseases
to be one of the biggest unsolved problems of modern society. Despite the progress in …

Mitochondria are unique and essential organelles that mediate many vital cellular processes
including energy metabolism and cell death. The transcription factor Nrf2 (NF-E2 p45 …

Mitochondria are major sources of reactive oxygen species (ROS) within the cell and are
especially vulnerable to oxidative stress. Oxidative damage to mitochondria results in …

Neuroinflammation and reactive oxygen and nitrogen species are rapidly induced in the
brain after acute cerebral injuries that are associated with an enhanced risk for epilepsy in …

One of the most important characteristics of the brain compared to other organs is its
elevated metabolic demand. Consequently, neurons consume high quantities of oxygen …

The roles of both neuroinflammation and oxidative stress in the pathophysiology of epilepsy
have begun to receive considerable attention in recent years. However, these concepts are …

The nuclear factor erythroid 2-related factor 2 (NRF2)–Kelch-like ECH-associated protein 1
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …

The transcription factor Nrf2 and its repressor Keap1 mediate cell stress adaptation by
inducing expression of genes regulating cellular detoxification, antioxidant defence and …