Ulcerative colitis (UC) specifically affects the colon and rectum through multifactorial
mechanisms associated with genetic alterations, environmental factors, microbiota, and …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal
tract. Cytokine-targeted therapies have transformed the treatment of IBD, providing control of …

In the last 10 years, we have learned much about the pathogenesis, diagnosis, and
management of intestinal fibrosis in patients with inflammatory bowel diseases. Just a …

Crohn's disease and ulcerative colitis are idiopathic, chronic, relapsing, inflammatory
conditions that are immunologically mediated. Although their exact etiologies remain …

IL-33 is a novel member of the IL-1 family and ligand for the IL-1 receptor-related protein,
ST2. Recent evidence suggests that the IL-33/ST2 axis plays a critical role in several …

Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition that is
medicated by genetic, immune, and environmental factors. At least 66 different kinds of …

The gut microbiota plays a major role in the developmental biology and homeostasis of cells
belonging to the adaptive and innate arms of the immune system. Alterations in its …

The specific pathogenesis underlining inflammatory bowel disease (IBD) is very
complicated, and it is further more difficult to clearly explain the pathophysiology of 2 major …

There are now many experimental models of inflammatory bowel disease (IBD), most of
which are due to induced mutations in mice that result in an impaired homeostasis with the …

Intestinal fibrosis is a common and potentially serious complication of IBD that results from
the reaction of intestinal tissue to the damage inflicted by chronic inflammation. The …