Bone has well documented natural healing capacity that normally is sufficient to repair
fractures and other common injuries. However, the properties of bone change throughout …

Postmenopausal osteoporosis (PMOP) is a prevalent skeletal disorder associated with
menopause-related estrogen withdrawal. PMOP is characterized by low bone mass …

Imbalance between osteoblasts and osteoclasts accounts for the incidence and
deterioration of postmenopausal osteoporosis. Abnormally elevated RANKL and TNF-α …

Long-chain polyunsaturated fatty acids (LCPUFAs) and their metabolites are considered
essential factors to support bone and joint health. The n-6 PUFAs suppress the osteoblasts …

The complicated connections and cross talk between the skeletal system and the immune
system are attracting more attention, which is developing into the field of Osteoimmunology …

Estrogens (estradiol, estriol, and estrone) are important hormones that directly and indirectly
regulate the metabolism and function of bone and skeletal muscle via estrogen receptors …

The loss of estrogen (E2) initiates a rapid phase of bone loss leading to osteoporosis in one‐
half of postmenopausal women, but the mechanism is not fully understood. Here, we show …

Non-traumatic osteonecrosis of the femoral head (NONFH) remains a common refractory
disease with poorly understood pathogenesis. Macrophage M1/M2 imbalance and chronic …

Elevated osteoclast (OC) activity is a major contributor to inflammatory bone loss (IBL)
during chronic inflammatory diseases. However, the specific OC precursors (OCPs) …

Resveratrol (RSV)(3, 5, 4′-trihydroxystilbene) is a stilbene found in abundance in berry
fruits, peanuts, and some medicinal plants. It has a diverse range of pharmacological …