Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-
forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1-and …

Pyroptosis is a recently described mechanism of programmed cell death mediated by
proteins of the gasdermin family. Widely recognized signaling cascades include the …

Gasdermin E (GSDME), a gene originally involved in hereditary hearing loss, has been
associated with several types of cancer in the last two decades. Recently, GSDME was …

Pyroptosis is a recently identified type of lytic programmed cell death, in which pores form in
the plasma membrane, and cells swell, rupture, and then release their contents, including …

Age-related (AR) hearing loss (HL) is a prevalent sensory deficit in the elderly population.
Several studies showed that common variants increase ARHL susceptibility. Here, we …

Nonsyndromic hearing loss (NSHL) is a genetically diverse, highly heterogeneous condition
characterised by deafness, and Gasdermin E (GSDME) variants have been identified as …

Autosomal dominant non-syndromic hearing loss (ADNSHL) displays gene-specific
progression of hearing loss, which is amenable to sequential audioprofiling. We sought to …

Background Hearing loss is considered one of the most common sensory nervous system
defects, about 60% of which are caused by genetic factors. Mutations in the GSDME gene …

Background The most frequent clinical presentation of autosomal dominant nonsyndromic
hearing loss (ADNSHL) is bilateral, symmetrical, postlingual progressive sensorineural …

GSDME, also known as DFNA5, is a gene implicated in autosomal dominant nonsyndromic
hearing loss (ADNSHL), affecting, at first, the high frequencies with a subsequent …