[HTML][HTML] Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis
Y Feng, M Spezia, S Huang, C Yuan, Z Zeng, L Zhang… - Genes & diseases, 2018 - Elsevier
As the most commonly occurring cancer in women worldwide, breast cancer poses a
formidable public health challenge on a global scale. Breast cancer consists of a group of …
formidable public health challenge on a global scale. Breast cancer consists of a group of …
Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins
Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …
breaks in mammalian cells, the defining step of which is homologous strand exchange …
NCCN guidelines insights: genetic/familial high-risk assessment: breast and ovarian, version 2.2017
MB Daly, R Pilarski, M Berry, SS Buys… - Journal of the National …, 2017 - jnccn.org
The NCCN Clinical Practice Guidelines in Oncology for Genetic/Familial High-Risk
Assessment: Breast and Ovarian provide recommendations for genetic testing and …
Assessment: Breast and Ovarian provide recommendations for genetic testing and …
Breast-Cancer Risk in Families with Mutations in PALB2
AC Antoniou, S Casadei, T Heikkinen… - … England Journal of …, 2014 - Mass Medical Soc
Background Germline loss-of-function mutations in PALB2 are known to confer a
predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred …
predisposition to breast cancer. However, the lifetime risk of breast cancer that is conferred …
[HTML][HTML] Addressing the challenges of pancreatic cancer: future directions for improving outcomes
Pancreatic ductal adenocarcinoma (PDAC), which accounts for more than 90% of all
pancreatic tumours, is a devastating malignancy with an extremely poor prognosis, as …
pancreatic tumours, is a devastating malignancy with an extremely poor prognosis, as …
Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition
LR Ferguson, H Chen, AR Collins, M Connell… - Seminars in cancer …, 2015 - Elsevier
Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …
prognosis of the affected patient. Genomic instability arises from many different pathways …
The BRCA tumor suppressor network in chromosome damage repair by homologous recombination
Mutations in the BRCA1 and BRCA2 genes predispose afflicted individuals to breast,
ovarian, and other cancers. The BRCA-encoded products form complexes with other tumor …
ovarian, and other cancers. The BRCA-encoded products form complexes with other tumor …
Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer
S Casadei, BM Norquist, T Walsh, S Stray, JB Mandell… - Cancer research, 2011 - AACR
Inherited mutations in the BRCA2-interacting protein PALB2 are known to be associated
with increased risks of developing breast cancer. To evaluate the contribution of PALB2 to …
with increased risks of developing breast cancer. To evaluate the contribution of PALB2 to …
PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function
PALB2/FANCN is mutated in breast and pancreatic cancers and Fanconi anemia (FA). It
controls the intranuclear localization, stability, and DNA repair function of BRCA2 and links …
controls the intranuclear localization, stability, and DNA repair function of BRCA2 and links …
BRCA1-Dependent and independent recruitment of PALB2–BRCA2–RAD51 in the DNA damage response and Cancer
Abstract The BRCA1–PALB2–BRCA2 axis plays essential roles in the cellular response to
DNA double-strand breaks (DSB), maintenance of genome integrity, and suppression of …
DNA double-strand breaks (DSB), maintenance of genome integrity, and suppression of …