Drug development is a long process whose main content includes drug synthesis, drug
delivery, and drug evaluation. Compared with conventional drug development procedures …

Background In recent years, there has been a surge in the development and application of
single-cell genomics, transcriptomics, proteomics, and metabolomics. The metabolome is …

Proteins are involved in many biological processes. Misfolded, truncated, or mutated
proteins as well as over-or underexpressed proteins have been implicated in many …

Single-cell proteomics (SCP) has great potential to advance biomedical research and
personalized medicine. The sensitivity of such measurements increases with low-flow …

Despite longstanding appreciation of gene expression heterogeneity in isogenic bacterial
populations, affordable and scalable technologies for studying single bacterial cells have …

Substantial evidence shows that the heterogeneity of individual cells within a genetically
identical population can be critical to their chance of survival. Methods that use average …

Microfluidics and novel lab-on-a-chip applications have the potential to boost
biotechnological research in ways that are not possible using traditional methods. Although …

Because of cellular heterogeneity, the analysis of endogenous molecules from single cells is
of significant interest and has major implications. While micromanipulation or cell sorting …

The intracellular levels and spatial localizations of metabolites and peptides reflect the state
of a cell and its relationship to its surrounding environment. Moreover, the amounts and …

Mass cytometry is attracting significant attention for enabling spatiotemporal high‐
throughput single‐cell analysis. As the first demonstration of the simultaneous detection of …