The role of T lymphocytes in the pathogenesis of asthma

M Larché, DS Robinson, AB Kay - Journal of Allergy and Clinical …, 2003 - Elsevier
Continuing Medical Education examination CONTINUING MEDICAL EDUCATION
ARTICLECredit can now be obtained, free for a limited time, by reading the following review …

Immunological aspects of allergic asthma.

BS Bochner, BJ Undem… - Annual review of …, 1994 - europepmc.org
Asthma is a chronic obstructive disease of the lower airways. It is characterized by episodic
exacerbations of at least partially reversible airflow limitation, along with bronchial …

Inflammation of small airways in asthma

Q Hamid, Y Song, TC Kotsimbos, E Minshall… - Journal of Allergy and …, 1997 - Elsevier
This study was designed to examine the inflammatory process in the central and peripheral
airways of surgically resected lungs from asthmatic and nonasthmatic subjects. Lung …

[HTML][HTML] Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production

L Cohn, RJ Homer, A Marinov, J Rankin… - The Journal of …, 1997 - ncbi.nlm.nih.gov
Airway inflammation is believed to stimulate mucus production in asthmatic patients.
Increased mucus secretion is an important clinical symptom and contributes to airway …

Increased vascularity of the bronchial mucosa in mild asthma

XUN Li, JW Wilson - American journal of respiratory and critical …, 1997 - atsjournals.org
Airway-wall remodeling leading to thickening of the bronchial wall in asthma has been
invoked to account for airflow obstruction and increased bronchial reactivity to provocative …

Airway inflammation in mild intermittent and in persistent asthma

AM Vignola, P Chanez, AM Campbell… - American journal of …, 1998 - atsjournals.org
The severity of asthma can be graded from mild intermittent to severe persistent. Airway
inflammation is a feature of persistent asthma. We compared several markers of …

Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy.

ER Sher, DY Leung, W Surs, JC Kam… - The Journal of …, 1994 - Am Soc Clin Investig
The current study examined whether alterations in glucocorticoid receptor (GR) binding
contribute to poor response to glucocorticoid therapy in asthma. 29 asthma patients with …

Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis

DL Hamilos, DYM Leung, R Wood… - Journal of allergy and …, 1995 - Elsevier
Background: The purpose of this study was to characterize the relationship between tissue
cytokine expression and the cellular infiltrate present in chronic hyperplastic sinusitis with …

[HTML][HTML] Allergen-induced IL-9 directly stimulates mucin transcription in respiratory epithelial cells

M Longphre, D Li, M Gallup, E Drori… - The Journal of …, 1999 - Am Soc Clin Investig
A hallmark of asthma is mucin overproduction, a condition that contributes to airway
obstruction. The events responsible for mucin overproduction are not known but are thought …

[HTML][HTML] Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation

DA Randolph, R Stephens… - The Journal of …, 1999 - Am Soc Clin Investig
We have studied the actions of helper T lymphocyte-1 and-2 (Th1 and Th2) cells in an acute
model of eosinophilic airway inflammation by infusing chicken ovalbumin-specific (OVA …