Simple Summary Ovarian cancer is a lethal disease in women with a 10-year survival rate
of< 40% worldwide. A key molecular alteration in ovarian cancer is the aberrant …

Ovarian cancer is the most lethal gynecologic malignancy, and patient prognosis has not
improved significantly over the last several decades. In order to improve therapeutic …

We present a systematic analysis of the effects of synchronizing a large-scale, deeply
characterized, multi-omic dataset to the current human reference genome, using updated …

PAX8 is a master transcription factor that is essential during embryogenesis and promotes
neoplastic growth. It is expressed by the secretory cells lining the female reproductive tract …

High grade serous ovarian cancer (HGSC) arises from the fimbriated end of the fallopian
tube epithelium (FTE), and in some cases, the ovarian surface epithelium (OSE). PAX8 is a …

Paired-box (PAX) genes encode a family of highly conserved transcription factors found in
vertebrates and invertebrates. PAX proteins are defined by the presence of a paired domain …

Müllerian tissue-specific oncogenes, prototyped by PAX8, underlie ovarian tumorigenesis
and represent unique molecular vulnerabilities. Further delineating such lineage …

Background: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive
malignancies, with no effective treatment currently available. The molecular mechanisms of …

High-grade serous ovarian cancer is a deadly disease that can originate from the fallopian
tube or the ovarian surface epithelium. The PAX (paired box) genes PAX2 and PAX8 are …

Simple Summary Ovarian high-grade serous cancer (HGSC), the most common and the
deadliest subtype of epithelial ovarian cancer, is characterized by frequent mutations in the …