Recent drug development efforts targeting Alzheimer's disease (AD) have failed to produce
effective disease-modifying agents for many reasons, including the substantial …

Unnatural helical peptidic foldamers have attracted considerable attention owing to their
unique folding behaviours, diverse artificial protein binding mechanisms, and promising …

Intra-tumoral heterogeneity is a hallmark of glioblastoma that challenges treatment efficacy.
However, the mechanisms that set up tumor heterogeneity and tumor cell migration remain …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a serious threat to
human health and lacks an effective treatment. There is an urgent need for both real-time …

Missense mutations in p53 are severely deleterious and occur in over 50% of all human
cancers. The majority of these mutations are located in the inherently unstable DNA-binding …

Similar to neurodegenerative diseases, the concept that tumors are prion like diseases has
been proposed in recent years. p53, the most well-known tumor suppressor, has been …

In a three-dimensional (3D) representation, each protein molecule displays a specific
pattern of chemical and topological features, which are altered during its misfolding and …

Cell–cell communication plays a vital role in biological activities; in particular, membrane–
protein interactions are profoundly significant. In order to explore the underlying mechanism …

Amyloid proteins and peptides are a major contributing factor to the development of various
neurodegenerative disorders, including Alzheimer's and prion diseases. Previously, a …

An interruption in Aβ homeostasis leads to the deposit of neurotoxic amyloid plaques and is
associated with Alzheimer's disease. A supramolecular strategy based on the assembly of …