Management of oxidative stress and other pathologies in Alzheimer's disease

M Simunkova, SH Alwasel, IM Alhazza, K Jomova… - Archives of …, 2019 - Springer
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder, characterized by
the formation, aggregation and accumulation of amyloid beta, perturbed metal (copper, iron …

Alzheimer's disease: updated multi-targets therapeutics are in clinical and in progress

Z Sang, K Wang, J Dong, L Tang - European journal of medicinal chemistry, 2022 - Elsevier
Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting
over 30 million people globally. Currently, no effective treatment is available due to multiple …

Molecular hybridization as a tool for designing multitarget drug candidates for complex diseases

V Ivasiv, C Albertini, AE Gonçalves… - Current Topics in …, 2019 - ingentaconnect.com
Molecular hybridization is a well-exploited medicinal chemistry strategy that aims to combine
two molecules (or parts of them) in a new, single chemical entity. Recently, it has been …

Rational design of multitarget-directed ligands: strategies and emerging paradigms

J Zhou, X Jiang, S He, H Jiang, F Feng… - Journal of medicinal …, 2019 - ACS Publications
Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit
satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation …

Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments

M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …

Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease

N Kumar, V Kumar, P Anand, V Kumar… - Bioorganic & Medicinal …, 2022 - Elsevier
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …

Current pharmacotherapy and multi-target approaches for Alzheimer's disease

SL Cheong, JK Tiew, YH Fong, HW Leong, YM Chan… - Pharmaceuticals, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by decreased
synaptic transmission and cerebral atrophy with appearance of amyloid plaques and …

Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in …

P Ganesan, P Ramalingam… - International journal …, 2018 - Taylor & Francis
Solid lipid nanoparticle (SLN) delivery systems have a wide applicability in the delivery of
phyto-bioactive compounds to treat various chronic diseases, including diabetes, cancer …

Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998–2018)

P Mishra, A Kumar, G Panda - Bioorganic & Medicinal Chemistry, 2019 - Elsevier
Alzheimer's disease (AD) is a genetically complex, progressive and irreversible
neurodegenerative disorder of the brain which involves multiple associated etiological …

Mechanistic insights for drug repurposing and the design of hybrid drugs for Alzheimer's disease

D Padhi, T Govindaraju - Journal of Medicinal Chemistry, 2022 - ACS Publications
The heterogeneity and complex nature of Alzheimer's disease (AD) is attributed to several
genetic risk factors and molecular culprits. The slow pace and increasing failure rate of …