The gut microbiome and metabolic syndrome

K Dabke, G Hendrick, S Devkota - The Journal of clinical …, 2019 - Am Soc Clin Investig
The metabolic syndrome (MetS) is a constellation of risk factors that, if left untreated, will
often progress to greater metabolic defects such as type 2 diabetes and nonalcoholic fatty …

Understanding the impact of antibiotic perturbation on the human microbiome

DJ Schwartz, AE Langdon, G Dantas - Genome medicine, 2020 - Springer
The human gut microbiome is a dynamic collection of bacteria, archaea, fungi, and viruses
that performs essential functions for immune development, pathogen colonization …

Environmental factors shaping the gut microbiome in a Dutch population

R Gacesa, A Kurilshikov, A Vich Vila, T Sinha… - Nature, 2022 - nature.com
The gut microbiome is associated with diverse diseases,–, but a universal signature of a
healthy or unhealthy microbiome has not been identified, and there is a need to understand …

inStrain profiles population microdiversity from metagenomic data and sensitively detects shared microbial strains

MR Olm, A Crits-Christoph, K Bouma-Gregson… - Nature …, 2021 - nature.com
Coexisting microbial cells of the same species often exhibit genetic variation that can affect
phenotypes ranging from nutrient preference to pathogenicity. Here we present inStrain, a …

The gut microbiota in the first decade of life

M Derrien, AS Alvarez, WM de Vos - Trends in microbiology, 2019 - cell.com
Appreciation of the importance of the gut microbiome is growing, and it is becoming
increasingly relevant to identify preventive or therapeutic solutions targeting it. The …

Mobile genetic elements from the maternal microbiome shape infant gut microbial assembly and metabolism

T Vatanen, KS Jabbar, T Ruohtula, J Honkanen… - Cell, 2022 - cell.com
The perinatal period represents a critical window for cognitive and immune system
development, promoted by maternal and infant gut microbiomes and their metabolites. Here …

[HTML][HTML] The long-term genetic stability and individual specificity of the human gut microbiome

L Chen, D Wang, S Garmaeva, A Kurilshikov, AV Vila… - Cell, 2021 - cell.com
By following up the gut microbiome, 51 human phenotypes and plasma levels of 1,183
metabolites in 338 individuals after 4 years, we characterize microbial stability and variation …

Breastmilk feeding practices are associated with the co-occurrence of bacteria in mothers' milk and the infant gut: the CHILD cohort study

K Fehr, S Moossavi, H Sbihi, RCT Boutin, L Bode… - Cell host & …, 2020 - cell.com
Gut microbiota play a critical role in infant health. It is now accepted that breastmilk contains
live bacteria from endogenous and exogenous sources, but it remains unclear whether …

Neonatal antibiotic exposure impairs child growth during the first six years of life by perturbing intestinal microbial colonization

A Uzan-Yulzari, O Turta, A Belogolovski, O Ziv… - Nature …, 2021 - nature.com
Exposure to antibiotics in the first days of life is thought to affect various physiological
aspects of neonatal development. Here, we investigate the long-term impact of antibiotic …

[HTML][HTML] Establishing what constitutes a healthy human gut microbiome: state of the science, regulatory considerations, and future directions

MI McBurney, C Davis, CM Fraser, BO Schneeman… - The Journal of …, 2019 - Elsevier
ABSTRACT On December 17, 2018, the North American branch of the International Life
Sciences Institute (ILSI North America) convened a workshop “Can We Begin to Define a …