Receptor tyrosine kinases (RTKs) play a crucial role in cellular signaling and oncogenic
progression. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) have …

The vast amount of available sequencing data allows the scientific community to explore
different genetic alterations that may drive cancer or favor cancer progression. Software …

Designing functionalized MOFs with specific reactivity and NIR photoelectrochemical and
fluorescent response is critical for developing biosensing systems. Herein, SCy7, a …

Alterations in the exonuclease domain of DNA polymerase ε cause ultramutated cancers.
These cancers accumulate AGA> ATA transversions; however, their genomic features …

The poor prognosis of glioma patients brought attention to the need for effective therapeutic
approaches for precision therapy. Here, we deployed algorithms relying on network …

Lysosomal acid sphingomyelinase (ASM), a critical enzyme in lipid metabolism encoded by
the SMPD1 gene, plays a crucial role in sphingomyelin hydrolysis in lysosomes. ASM …

Motivation Genomic instability is a hallmark of cancer, leading to many somatic alterations.
Identifying which alterations have a system-wide impact is a challenging task. Nevertheless …

Purpose: Patient-tailored minimal residual disease (MRD) monitoring based on circulating
tumor DNA (ctDNA) sequencing of leukemia-specific mutations enables early detection of …

Weak molecular interactions play an important role in protein structure and function.
Computational tools that identify weak molecular interactions are, therefore, valuable for the …

Optical spectroscopic techniques relying on light–matter interactions, such as Raman
scattering, fluorescence, and infrared absorbance spectroscopy, offer numerous advantages …