Cardiovascular disease (CVD) is a leading cause of death worldwide and continues to
increase in prevalence compared to previous decades, in part because of the aging of the …

Despite advances in myocardial reperfusion therapies, acute myocardial
ischaemia/reperfusion injury and consequent ischaemic heart failure represent the number …

Background—Microarrays have been used extensively to profile transcriptome remodeling
in failing human heart, although the genomic coverage provided is limited and fails to …

Background Current heart failure (HF) treatment is based on targeting symptoms and left
ventricle dysfunction severity, relying on a common HF pathway paradigm to justify common …

Heart failure is a complex clinical syndrome and has become the most common reason for
adult hospitalization in developed countries. Two subtypes of heart failure, ischemic heart …

MicroRNAs are recently discovered regulators of gene expression and are becoming
increasingly recognized as important regulators of heart function. Genome-wide profiling of …

Background—Much has been learned about transcriptional control of cardiac gene
expression in clinical and experimental congestive heart failure (CHF), but less is known …

Cardiomyopathy can be initiated by many factors, but the pathways from unique inciting
mechanisms to the common end point of ventricular dilation and reduced cardiac output are …

Background—Alternative mRNA splicing is an important mechanism for regulation of gene
expression. Altered mRNA splicing occurs in association with several types of cancer, and a …

Background: Extensive evidence from single-center studies indicates that a subset of
patients with chronic advanced heart failure (HF) undergoing left ventricular assist device …