[HTML][HTML] The prodomain of bone morphogenetic protein 2 promotes dimerization and cleavage of BMP6 homodimers and BMP2/6 heterodimers

P Chauhan, Y Xue, HS Kim, AL Fisher, JL Babitt… - Journal of Biological …, 2024 - Elsevier
Abstract Bone morphogenetic protein 2 (BMP2) and BMP6 are key regulators of systemic
iron homeostasis. All BMPs are generated as inactive precursor proteins that dimerize and …

Tril dampens Nodal signaling through Pellino2-and Traf6-mediated activation of Nedd4l

HS Kim, YS Green, Y Xie… - Proceedings of the …, 2021 - National Acad Sciences
Toll-like receptor 4 (Tlr) interactor with leucine-rich repeats (Tril) functions as a Tlr coreceptor
to mediate innate immunity in adults. In Xenopus embryos, Tril triggers degradation of the …

QTL-mapping in the obese Berlin Fat Mouse identifies additional candidate genes for obesity and fatty liver disease

M Delpero, D Arends, A Freiberg, GA Brockmann… - Scientific Reports, 2022 - nature.com
Abstract The Berlin Fat Mouse Inbred line (BFMI) is a model for obesity and the metabolic
syndrome. This study aimed to identify genetic variants associated with liver weight, liver …

Identification of new candidate genes associated with metabolic traits applying a multiomics approach in the obese mouse model BFMI861

M Delpero - 2023 - edoc.hu-berlin.de
Background: The Berlin Fat Mouse Inbred line (BFMI) is a model for obesity and the
metabolic syndrome. This study aimed to identify genetic variants associated with the …