The perception that intracellular lipolysis is a straightforward process that releases fatty
acids from fat stores in adipose tissue to generate energy has experienced major revisions …

Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Adipose tissue is usually classified on the basis of its function as white, brown or beige
(brite). It is an important regulator of systemic metabolism, as shown by the fact that …

Obesity is characterized by increased adipose tissue mass and has been associated with a
strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public …

The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Thermogenic adipocytes possess a therapeutically appealing, energy-expending capacity,
which is canonically cold-induced by ligand-dependent activation of β-adrenergic G protein …

Obesity is one of the main risk factors for type 2 diabetes mellitus (T2DM). It is closely related
to metabolic disturbances in the adipose tissue that primarily functions as a fat reservoir. For …

Infants rely on brown adipose tissue (BAT) as a primary source of thermogenesis. In some
adult humans, residuals of brown adipose tissue are adjacent to the central nervous system …

The BMP2/4 antagonist and novel adipokine Gremlin 1 is highly expressed in human
adipose cells and increased in hypertrophic obesity. As a secreted antagonist, it inhibits the …

Obesity is the result of energy intake chronically exceeding energy expenditure. Classical
treatments against obesity do not provide a satisfactory long‐term outcome for the majority of …