Large epidemiological and health impact assessment studies at the global scale, such as
the Global Burden of Disease project, indicate that chronic non-communicable diseases …

The concept of the exposome was introduced over 15 years ago to reflect the important role
that the environment exerts on health and disease. While originally viewed as a call-to-arms …

The concept of the exposome was developed to draw attention to the critical need for more
complete environmental exposure assessment in epidemiological studies; 1–4 environment …

Derived from the term exposure, the exposome is an omic-scale characterization of the
nongenetic drivers of health and disease. With the genome, it defines the phenome of an …

Exposure to airborne fine particles (PM2. 5, particulate matter with aerodynamic diameter<
2.5 μm) severely threatens global human health. Understanding the distribution and …

The food metabolome is defined as the part of the human metabolome directly derived from
the digestion and biotransformation of foods and their constituents. With> 25,000 …

Abstract EXPOsOMICS is a European Union funded project that aims to develop a novel
approach to the assessment of exposure to high priority environmental pollutants, by …

The cysteine (Cys) proteome is a major component of the adaptive interface between the
genome and the exposome. The thiol moiety of Cys undergoes a range of biologic …

The risk assessment of chemical carcinogens is one major task in toxicology. Even though
exposure has been mitigated effectively during the last decades, low levels of carcinogenic …

Systems Toxicology is the integration of classical toxicology with quantitative analysis of
large networks of molecular and functional changes occurring across multiple levels of …