More and more cancer patients receive surgery and chronic pain control. Cell-mediated
immunosuppression from surgical stress renders perioperative period a vulnerable period …

The surgical stress response and resulting physiologic changes can lead to postoperative
complications and negatively impact animal welfare. Although appropriate pain …

PURPOSE: To determine the effects of mixing anesthetics or corticosteroids with platelet-rich
plasma (PRP) on human tenocytes in vitro. METHODS: Two separate protocols (double spin …

In a nanotechnological approach we have investigated the use of natural lipids in the
preparation of nanostructured lipid carriers (NLC). Three different NLC composed of copaiba …

Cancer causes considerable suffering and 80% of advanced cancer patients experience
moderate to severe pain. Surgical tumor excision remains a cornerstone of primary cancer …

BACKGROUND: Although local anesthetics (LAs) are generally accepted as being safe,
incidental neuronal damage has been reported for all LAs in humans. Therefore, in this …

During the second half of the last century, the prevalent knowledge recognized the voltage-
gated sodium channels (VGSCs) as the proteins responsible for the generation and …

Background Adipose stem cells have gained great interest in plastic and reconstructive
surgery with their ability to improve engraftment after fat transfer for soft tissue filling. It is …

Surgical removal of solid tumors is of utmost importance as total resection can be curative.
The surgical insult however itself may result in tumor micrometastasis coupled with …

Background: Concern has recently arisen over the safety of local anesthetics used on
human tissues. Hypothesis: Aminoamide local anesthetics have cytotoxic effects on human …