Riboswitch-mediated gene regulation: novel RNA architectures dictate gene expression responses

AV Sherwood, TM Henkin - Annual review of microbiology, 2016 - annualreviews.org
Riboswitches are RNA elements that act on the mRNA with which they are cotranscribed to
modulate expression of that mRNA. These elements are widely found in bacteria, where …

Riboswitches: discovery of drugs that target bacterial gene-regulatory RNAs

KE Deigan, AR FerrÉ-D'AmarÉ - Accounts of chemical research, 2011 - ACS Publications
Riboswitches are messenger RNA (mRNA) domains that regulate gene function in response
to the intracellular concentration of a variety of metabolites and second messengers. They …

Three-state mechanism couples ligand and temperature sensing in riboswitches

A Reining, S Nozinovic, K Schlepckow, F Buhr, B Fürtig… - Nature, 2013 - nature.com
Riboswitches are cis-acting gene-regulatory RNA elements that can function at the level of
transcription, translation and RNA cleavage,,. The commonly accepted molecular …

An excited state underlies gene regulation of a transcriptional riboswitch

B Zhao, SL Guffy, B Williams, Q Zhang - Nature chemical biology, 2017 - nature.com
Riboswitches control gene expression through ligand-dependent structural rearrangements
of the sensing aptamer domain. However, we found that the Bacillus cereus fluoride …

The dynamic nature of RNA as key to understanding riboswitch mechanisms

A Haller, MF Soulière, R Micura - Accounts of chemical research, 2011 - ACS Publications
Riboswitches are gene regulation elements within RNA that recognize specific metabolites.
They predominantly occur in the untranslated leader regions of bacterial messenger RNA …

Conformational capture of the SAM-II riboswitch

A Haller, U Rieder, M Aigner, SC Blanchard… - Nature chemical …, 2011 - nature.com
Riboswitches are gene regulation elements in mRNA that function by specifically
responding to metabolites. Although the metabolite-bound states of riboswitches have …

Metabolite recognition principles and molecular mechanisms underlying riboswitch function

A Serganov, DJ Patel - Annual review of biophysics, 2012 - annualreviews.org
Riboswitches are mRNA elements capable of modulating gene expression in response to
specific binding by cellular metabolites. Riboswitches exert their function through the …

Molecular sensing by the aptamer domain of the FMN riboswitch: a general model for ligand binding by conformational selection

Q Vicens, E Mondragón, RT Batey - Nucleic acids research, 2011 - academic.oup.com
Understanding the nature of the free state of riboswitch aptamers is important for illuminating
common themes in gene regulation by riboswitches. Prior evidence indicated the flavin …

Molecular recognition and function of riboswitches

A Serganov, DJ Patel - Current opinion in structural biology, 2012 - Elsevier
Regulatory mRNAs elements termed riboswitches respond to elevated concentrations of
cellular metabolites by modulating expression of associated genes. Riboswitches attain their …

The Shine-Dalgarno sequence of riboswitch-regulated single mRNAs shows ligand-dependent accessibility bursts

AJ Rinaldi, PE Lund, MR Blanco, NG Walter - Nature communications, 2016 - nature.com
In response to intracellular signals in Gram-negative bacteria, translational riboswitches—
commonly embedded in messenger RNAs (mRNAs)—regulate gene expression through …