Riboswitch-mediated gene regulation: novel RNA architectures dictate gene expression responses
AV Sherwood, TM Henkin - Annual review of microbiology, 2016 - annualreviews.org
Riboswitches are RNA elements that act on the mRNA with which they are cotranscribed to
modulate expression of that mRNA. These elements are widely found in bacteria, where …
modulate expression of that mRNA. These elements are widely found in bacteria, where …
Riboswitches: discovery of drugs that target bacterial gene-regulatory RNAs
KE Deigan, AR FerrÉ-D'AmarÉ - Accounts of chemical research, 2011 - ACS Publications
Riboswitches are messenger RNA (mRNA) domains that regulate gene function in response
to the intracellular concentration of a variety of metabolites and second messengers. They …
to the intracellular concentration of a variety of metabolites and second messengers. They …
Three-state mechanism couples ligand and temperature sensing in riboswitches
Riboswitches are cis-acting gene-regulatory RNA elements that can function at the level of
transcription, translation and RNA cleavage,,. The commonly accepted molecular …
transcription, translation and RNA cleavage,,. The commonly accepted molecular …
An excited state underlies gene regulation of a transcriptional riboswitch
B Zhao, SL Guffy, B Williams, Q Zhang - Nature chemical biology, 2017 - nature.com
Riboswitches control gene expression through ligand-dependent structural rearrangements
of the sensing aptamer domain. However, we found that the Bacillus cereus fluoride …
of the sensing aptamer domain. However, we found that the Bacillus cereus fluoride …
The dynamic nature of RNA as key to understanding riboswitch mechanisms
A Haller, MF Soulière, R Micura - Accounts of chemical research, 2011 - ACS Publications
Riboswitches are gene regulation elements within RNA that recognize specific metabolites.
They predominantly occur in the untranslated leader regions of bacterial messenger RNA …
They predominantly occur in the untranslated leader regions of bacterial messenger RNA …
Conformational capture of the SAM-II riboswitch
A Haller, U Rieder, M Aigner, SC Blanchard… - Nature chemical …, 2011 - nature.com
Riboswitches are gene regulation elements in mRNA that function by specifically
responding to metabolites. Although the metabolite-bound states of riboswitches have …
responding to metabolites. Although the metabolite-bound states of riboswitches have …
Metabolite recognition principles and molecular mechanisms underlying riboswitch function
A Serganov, DJ Patel - Annual review of biophysics, 2012 - annualreviews.org
Riboswitches are mRNA elements capable of modulating gene expression in response to
specific binding by cellular metabolites. Riboswitches exert their function through the …
specific binding by cellular metabolites. Riboswitches exert their function through the …
Molecular sensing by the aptamer domain of the FMN riboswitch: a general model for ligand binding by conformational selection
Understanding the nature of the free state of riboswitch aptamers is important for illuminating
common themes in gene regulation by riboswitches. Prior evidence indicated the flavin …
common themes in gene regulation by riboswitches. Prior evidence indicated the flavin …
Molecular recognition and function of riboswitches
A Serganov, DJ Patel - Current opinion in structural biology, 2012 - Elsevier
Regulatory mRNAs elements termed riboswitches respond to elevated concentrations of
cellular metabolites by modulating expression of associated genes. Riboswitches attain their …
cellular metabolites by modulating expression of associated genes. Riboswitches attain their …
The Shine-Dalgarno sequence of riboswitch-regulated single mRNAs shows ligand-dependent accessibility bursts
In response to intracellular signals in Gram-negative bacteria, translational riboswitches—
commonly embedded in messenger RNAs (mRNAs)—regulate gene expression through …
commonly embedded in messenger RNAs (mRNAs)—regulate gene expression through …