The plasma membrane in eukaryotic cells contains microdomains that are enriched in
certain glycosphingolipids, gangliosides, and sterols (such as cholesterol) to form …

Receptor signaling relays on intracellular events amplified by secondary and tertiary
messenger molecules. In cardiomyocytes and smooth muscle cells, cyclic AMP (cAMP) and …

Rationale: It is unknown whether every ventricular myocyte expresses all 5 of the cardiac
adrenergic receptors (ARs), β1, β2, β3, α1A, and α1B. The β1 and β2 are thought to be the …

As described in the literature the interaction between cholesterol and membrane proteins
can occur via direct, ligand-like and indirect mechanisms, in which cholesterol effects are …

Cardiac contractility is regulated by several neural, hormonal, paracrine, and autocrine
factors. Amongst these, signaling through β-adrenergic and serotonin receptors generates …

The L-type Ca2+ channel Cav1. 2 controls multiple functions throughout the body including
heart rate and neuronal excitability. It is a key mediator of fight-or-flight stress responses …

The purpose of this study was to investigate whether caveolin-3 (Cav3) regulates
localization of β 2-adrenergic receptor (β 2 AR) and its cAMP signaling in healthy or failing …

G protein-coupled receptors (GPCRs) constitute the largest family of membrane receptors
and are of great interest as pharmacological targets. Although the occurrence of GPCR …

G protein-coupled receptors (GPCRs) are the largest family of membrane receptors and
mediate the effects of a multitude of extracellular cues, such as hormones, neurotransmitters …

Rationale: Compartmentation of ion channels on the cardiomyocyte surface is important for
electric propagation and electromechanical coupling. The specialized T-tubule and …