Chemokine receptors have a key role in the pathogenesis of autoimmune diseases,
inflammation and viral infection. However, with the exception of selective CCR5 antagonists …

A number of uncommon, clinically diverse and poorly understood inflammatory skin
diseases are linked by the presence of a set of histopathological elements that have …

Metal-catalyst-free, organic dye-catalyzed C3–H arylation of pyrido [1, 2-a] pyrimidin-4-ones
using visible light irradiation was developed under mild reaction conditions. This …

Direct C-3 arylation of imidazo [1, 2-a] pyridines with aryl tosylates and mesylates has been
accomplished by employing palladium (II) acetate associated with SPhos (2 …

Background: The first part of this two-part review discussed approaches to generating
antagonists for some of the CC chemokine receptors, including CCR1, CCR2, CCR3, and …

An expeditious metal free C-3 chalcogenation of 4H-pyrido [1, 2-a] pyrimidin-4-one has
been devised to synthesize diversely orchestrated 3-ArS/ArSe derivatives in high yields (up …

Chemokines and their receptors are known to play important roles in disease. More than 40
chemokine ligands and 20 chemokine receptors have been identified, but, to date, only two …

A lenient approach for regioselective C3− H chalcogenation and thiocyanation of 4H‐pyrido
[1, 2‐a] pyrimidin‐4‐ones is developed using visible light photocatalysis. This operationally …

The CXCR3 chemokine receptor was first discovered in 1996 and has been shown to play
an important role in several diseases, most of which are related to inflammation. This review …

Lead optimization efforts resulted in the discovery of two potent, selective, and orally
bioavailable PI3Kδ inhibitors, 1 (AM-8508) and 2 (AM-9635), with good pharmacokinetic …