This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …

The control of body and organ growth is essential for the development of adults with proper
size and proportions, which is important for survival and reproduction. In animals, adult body …

The Hippo signaling pathway is widely considered a master regulator of organ growth
because of the prominent overgrowth phenotypes caused by experimental manipulation of …

Organisms adapt to changing environments by adjusting their development, metabolism,
and behavior to improve their chances of survival and reproduction. To achieve such …

Studies in mammals and Drosophila have demonstrated the existence and significance of
secreted factors involved in communication between distal organs. In this review, primarily …

There is a large gap between the deep understanding of mechanisms driving tumour growth
and the reasons why patients ultimately die of cancer. It is now appreciated that interactions …

Animals display selective escape behaviors when faced with environmental threats.
Selection of the appropriate response by the underlying neuronal network is key to …

The insulin-like peptide (ILP) and insulin-like growth factor (IGF) signalling pathways play a
crucial role in the regulation of metabolism, growth and development, fecundity, stress …

Organ sizes and shapes are strikingly reproducible, despite the variable growth and division
of individual cells within them. To reveal which mechanisms enable this precision, we …

Hormones regulate development, as well as many vital processes in the daily life of an
animal. Many of these hormones are peptides that act at a higher hierarchical level in the …