The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease
Abstract The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …
cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such …
Gastroenteropancreatic neuroendocrine tumors
M Cives, JR Strosberg - CA: a cancer journal for clinicians, 2018 - Wiley Online Library
Neuroendocrine tumors (NETs) are heterogeneous malignancies arising from the diffuse
neuroendocrine system. They frequently originate in the gastroenteropancreatic (GEP) tract …
neuroendocrine system. They frequently originate in the gastroenteropancreatic (GEP) tract …
Signatures of copy number alterations in human cancer
Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …
[HTML][HTML] Gastroenteropancreatic neuroendocrine neoplasms: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
M Pavel, K Öberg, M Falconi, EP Krenning, A Sundin… - Annals of …, 2020 - Elsevier
Neuroendocrine neoplasms (NENs) arise from the diffuse neuroendocrine cell system and
may occur at many different disease sites. Most frequently, these neoplasms occur in the …
may occur at many different disease sites. Most frequently, these neoplasms occur in the …
[HTML][HTML] A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization …
The classification of neuroendocrine neoplasms (NENs) differs between organ systems and
currently causes considerable confusion. A uniform classification framework for NENs at any …
currently causes considerable confusion. A uniform classification framework for NENs at any …
Pan-cancer analysis of whole genomes
Nature, 2020 - nature.com
Cancer is driven by genetic change, and the advent of massively parallel sequencing has
enabled systematic documentation of this variation at the whole-genome scale,–. Here we …
enabled systematic documentation of this variation at the whole-genome scale,–. Here we …
Consensus guidelines for the use and interpretation of angiogenesis assays
The formation of new blood vessels, or angiogenesis, is a complex process that plays
important roles in growth and development, tissue and organ regeneration, as well as …
important roles in growth and development, tissue and organ regeneration, as well as …
[PDF][PDF] Comprehensive analysis of hypermutation in human cancer
We present an extensive assessment of mutation burden through sequencing analysis of>
81,000 tumors from pediatric and adult patients, including tumors with hypermutation caused …
81,000 tumors from pediatric and adult patients, including tumors with hypermutation caused …
The North American Neuroendocrine Tumor Society consensus paper on the surgical management of pancreatic neuroendocrine tumors
JR Howe, NB Merchant, C Conrad, XM Keutgen… - Pancreas, 2020 - journals.lww.com
This manuscript is the result of the North American Neuroendocrine Tumor Society
consensus conference on the surgical management of pancreatic neuroendocrine tumors …
consensus conference on the surgical management of pancreatic neuroendocrine tumors …
Genetic analysis of 779 advanced differentiated and anaplastic thyroid cancers
N Pozdeyev, LM Gay, ES Sokol, R Hartmaier… - Clinical Cancer …, 2018 - AACR
Purpose: To define the genetic landscape of advanced differentiated and anaplastic thyroid
cancer (ATC) and identify genetic alterations of potential diagnostic, prognostic, and …
cancer (ATC) and identify genetic alterations of potential diagnostic, prognostic, and …