Advanced age is the largest risk factor for late‐onset Alzheimer's disease (LOAD), a disease
in which susceptibility correlates to almost all hallmarks of aging. Shared genetic signatures …

Genome-wide association studies have identified thousands of loci associated with common
diseases and traits. However, a large fraction of heritability remains unexplained. Epigenetic …

Neurodegenerative diseases present complex genetic architectures, reflecting a continuum
from monogenic to oligogenic and polygenic models. Recent advances in multi-omics data …

Gene-gene (GxG) interactions play an important role in human genetics, potentially
explaining part of the “missing heritability” of polygenic traits and the variable expressivity of …

Impaired nitric oxide (NO) formation may be associated with endothelial dysfunction and
increased cardiovascular disease risk in preeclampsia (PE). Functional single-nucleotide …

The contribution of epistasis (interactions among genes or genetic variants) to human
complex trait variation remains poorly understood. Methods that aim to explicitly identify …

The combinatorial effect of genetic variants is often assumed to be additive. Although
genetic variation can clearly interact non-additively, methods to uncover epistatic …

Feature interactions are particularly useful in modeling biological effects, such as gene-gene
interactions, but are difficult to model due to the exponential increase in the feature space …

Adult height is a highly heritable polygenic trait with heritability attributable to thousands of
independent variants. Large-scale studies have been able to detect genetic variants with …

Genome-wide association studies have identified thousands of loci associated with common
diseases and traits. However, a large fraction of heritability remains unexplained. Epigenetic …