Disease Modifiers of Inherited SCN5A Channelopathy
AO Verkerk, AS Amin, CA Remme - Frontiers in Cardiovascular …, 2018 - frontiersin.org
To date, a large number of mutations in SCN5A, the gene encoding the pore-forming α-
subunit of the primary cardiac Na+ channel (NaV1. 5), have been found in patients …
subunit of the primary cardiac Na+ channel (NaV1. 5), have been found in patients …
Comprehensive review on methadone-induced QT prolongation and torsades
JM Treece, MA Madani, GE Khoury… - Journal of …, 2018 - journals.sagepub.com
An alternative analgesic to morphine is methadone, which is used to control chronic pain
and is used in opioid rehabilitation treatment programs due to methadone having a long half …
and is used in opioid rehabilitation treatment programs due to methadone having a long half …
Whole exome sequencing in Brugada and long QT syndromes revealed novel rare and potential pathogenic mutations related to the dysfunction of the cardiac sodium …
J Chen, H Li, S Guo, Z Yang, S Sun, JJ Zeng… - Orphanet Journal of …, 2022 - Springer
Abstract Background Brugada syndrome (Brs) and long QT syndrome (LQTs) are the most
observed “inherited primary arrhythmia syndromes” and “channelopathies”, which lead to …
observed “inherited primary arrhythmia syndromes” and “channelopathies”, which lead to …
Drug-mediated shortening of action potentials in LQTS2 human induced pluripotent stem cell-derived cardiomyocytes
G Duncan, K Firth, V George, MD Hoang… - Stem Cells and …, 2017 - liebertpub.com
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) are now
a well-established modality for modeling genetic disorders of the heart. This is especially so …
a well-established modality for modeling genetic disorders of the heart. This is especially so …
The genetics of sudden infant death syndrome—towards a gene reference resource
Sudden infant death syndrome (SIDS) is the unexpected death of an infant under one year
of age that remains unexplained after a thorough investigation. Despite SIDS remaining a …
of age that remains unexplained after a thorough investigation. Despite SIDS remaining a …
Fetal and Infant Effects of Maternal Opioid Use during Pregnancy: A Literature Review including Clinical, Toxicological, Pharmacogenomic, and Epigenetic Aspects for …
E Giovannini, MP Bonasoni, JP Pascali, C Bini… - Children, 2024 - mdpi.com
The two primary classes of opioid substances are morphine and its synthetic derivative,
heroin. Opioids can cross the placental barrier, reaching fetal circulation. Therefore, at any …
heroin. Opioids can cross the placental barrier, reaching fetal circulation. Therefore, at any …
Genes involved in paediatric apnoea and death based on knockout animal models: Implications for sudden infant death syndrome (SIDS)
E Stalley, KA Waters, R Machaalani - Paediatric Respiratory Reviews, 2022 - Elsevier
The mechanism of death in Sudden infant death syndrome (SIDS) remains unknown but it is
hypothesised that cardiorespiratory failure of brainstem origin results in early post-natal …
hypothesised that cardiorespiratory failure of brainstem origin results in early post-natal …
Early Screening for Long QT Syndrome and Cardiac Anomalies in Infants: A Comprehensive Study
L Nosetti, M Zaffanello, C Lombardi, A Gerosa… - Clinics and …, 2024 - mdpi.com
(1) Background: Sudden Infant Death Syndrome (SIDS) represents sudden and unexplained
deaths during the sleep of infants under one year of age, despite thorough investigation …
deaths during the sleep of infants under one year of age, despite thorough investigation …
Síndrome de muerte súbita del lactante: una revisión narrativa
CE Diaz, MV Zeas, AC Bueno, EB Maldonado… - … de Farmacología y …, 2019 - saber.ucv.ve
La definición del Síndrome de Muerte Súbita del Lactante (SMSL) es la muerte inesperada
de un niño antes de los 12meses durante el sueño ya la que no se le encuentra unacausa …
de un niño antes de los 12meses durante el sueño ya la que no se le encuentra unacausa …
Model-based estimation of QT intervals of mouse fetal electrocardiogram
N Widatalla, K Funamoto, M Kawataki… - BioMedical Engineering …, 2022 - Springer
Background Abnormal prolongation in the QT interval or long QT syndrome (LQTS) is
associated with several cardiac complications such as sudden infant death syndrome …
associated with several cardiac complications such as sudden infant death syndrome …