Abstract Hypericum perforatum L.(Clusiaceae), commonly known as St. John's wort, has a
rich historical background as one of the oldest and most widely studied herbal medicines …

Hyperforin is the compound responsible for the effectiveness of St. John's wort (Hypericum
perforatum) as an antidepressant, but its complete biosynthetic pathway remains unknown …

We report the first total synthesis of hypersampsone M, an archetypal member of the
homoadamantane polycyclic polyprenylated acylphloroglucinols (PPAPs). Commencing …

An asymmetric intramolecular hydroalkylation of unactivated internal olefins with tethered
cyclic ketones was realized by the cooperative catalysis of a newly designed chiral amine …

Polycyclic polyprenylated acylphloroglucinols (PPAPs) combine compelling structural
complexity with effective biological activity. The total synthesis of Hyperfirin is reported as …

Abstract Hymoins A–C (1–3), three unusual polycyclic polyprenylated acylphloroglucinols
(PPAPs) were isolated from the flowers of Hypericum monogynum. Hymoin A features the …

A bioinspired alkylation dearomatization reaction was developed to construct the 5/6/6 fused-
spiro tricyclic core framework and spiro-quaternary carbon chiral center. The usage of this …

Structurally unique natural products pose biosynthetic puzzles whose solution can inspire
new chemical reactions. Herein, we propose a unified biosynthetic pathway towards some …

Hyperireflexolides A and B were synthesized in six steps via the dearomatization and
fragmentation of a simple acylphloroglucinol starting material. The dearomatized …

Background: Natural products have optical activities with unusual structural characteristics
or specific stereoselectivity, mostly including spiro-ring systems or quaternary carbon atoms …