In this narrative review, the biological/biochemical impact (toxicity) of a large array of known
individual uremic retention solutes and groups of solutes is summarized. We classified these …

Objective: This review focuses on the current knowledge on the implication and significance
of beta 2 microglobulin (β2M), a conservative immune molecule in vertebrate. Data Sources …

Epithelial–mesenchymal transition (EMT) is defined by the loss of epithelial characteristics
and the acquisition of a mesenchymal phenotype. In this process, cells acquire molecular …

The epithelial–mesenchymal transition (EMT) has been postulated as a mechanism by
which cancer cells acquire the invasive and stem-like traits necessary for distant metastasis …

Tumor–stromal interaction is a dynamic process that promotes tumor growth and metastasis
via cell–cell interaction and extracellular vesicles. Recent studies demonstrate that stromal …

Cigarette smoke is a complex aerosol containing a large number of compounds with a
variety of toxicity and carcinogenicity. Long-term exposure to cigarette smoke significantly …

Immune checkpoint blockade (ICB) therapy is a powerful option for cancer treatment.
Despite demonstrable progress, most patients fail to respond or achieve durable responses …

Iron is indispensable for cell metabolism of both normal and cancer cells. In the latter,
several disruptions of its metabolism occur at the steps of tumor initiation, progression and …

Increased bone marrow adiposity is a common feature of advanced age, obesity and
associated metabolic pathologies. Augmented numbers of marrow adipocytes positively …

Cisplatin is a widely used chemotherapeutic agent that is clinically approved to fight both
carcinomas and sarcomas. It has relatively high efficiency in treating ovarian cancers and …