Biomedical engineering strategies for peripheral nerve repair: surgical applications, state of the art, and future challenges

BJ Pfister, T Gordon, JR Loverde… - Critical Reviews™ in …, 2011 - dl.begellhouse.com
Damage to the peripheral nervous system is surprisingly common and occurs primarily from
trauma or a complication of surgery. Although recovery of nerve function occurs in many mild …

Natural-based biomaterials for peripheral nerve injury repair

BE Fornasari, G Carta, G Gambarotta… - … in bioengineering and …, 2020 - frontiersin.org
Peripheral nerve injury treatment is a relevant problem because of nerve lesion high
incidence and because of unsatisfactory regeneration after severe injuries, thus resulting in …

The mechanosensitive ion channel piezo inhibits axon regeneration

Y Song, D Li, O Farrelly, L Miles, F Li, SE Kim, TY Lo… - Neuron, 2019 - cell.com
Neurons exhibit a limited ability of repair. Given that mechanical forces affect neuronal
outgrowth, it is important to investigate whether mechanosensitive ion channels may …

The emerging role of forces in axonal elongation

DM Suter, KE Miller - Progress in neurobiology, 2011 - Elsevier
An understanding of how axons elongate is needed to develop rational strategies to treat
neurological diseases and nerve injury. Growth cone-mediated neuronal elongation is …

Innervation: the missing link for biofabricated tissues and organs

S Das, WJ Gordián-Vélez, HC Ledebur… - NPJ Regenerative …, 2020 - nature.com
Innervation plays a pivotal role as a driver of tissue and organ development as well as a
means for their functional control and modulation. Therefore, innervation should be carefully …

Stretch growth of integrated axon tracts: extremes and exploitations

DH Smith - Progress in neurobiology, 2009 - Elsevier
Although virtually ignored in the literature until recently, the process of 'stretch growth of
integrated axon tracts' is perhaps the most remarkable axon growth mechanism of all. This …

Dysregulation of BRD4 function underlies the functional abnormalities of MeCP2 mutant neurons

Y Xiang, Y Tanaka, B Patterson, SM Hwang, E Hysolli… - Molecular cell, 2020 - cell.com
Rett syndrome (RTT), mainly caused by mutations in methyl-CpG binding protein 2
(MeCP2), is one of the most prevalent intellectual disorders without effective therapies. Here …

Concussion leads to widespread axonal sodium channel loss and disruption of the node of Ranvier

H Song, PP McEwan, KE Ameen-Ali, A Tomasevich… - Acta …, 2022 - Springer
Despite being a major health concern, little is known about the pathophysiological changes
that underly concussion. Nonetheless, emerging evidence suggests that selective damage …

Sodium channelopathy induced by mild axonal trauma worsens outcome after a repeat injury

TJ Yuen, KD Browne, A Iwata… - Journal of neuroscience …, 2009 - Wiley Online Library
There is great concern that one mild traumatic brain injury (mTBI) predisposes individuals to
an exacerbated response with a subsequent mTBI. Although no mechanism has been …

The orientation of the neuronal growth process can be directed via magnetic nanoparticles under an applied magnetic field

C Riggio, MP Calatayud, M Giannaccini, B Sanz… - … , Biology and Medicine, 2014 - Elsevier
There is a growing body of evidence indicating the importance of physical stimuli for
neuronal growth and development. Specifically, results from published experimental studies …