Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Quiescent cancer cells (QCCs) are nonproliferating cells arrested in the G0 phase,
characterized by ki67low and p27high. QCCs avoid most chemotherapies, and some …

The functions of the proto-oncoprotein c-Myc and the tumor suppressor p53 in controlling
cell survival and proliferation are inextricably linked as “Yin and Yang” partners in normal …

Rationale: Recurrent and metastatic cancers often undergo a period of dormancy, which is
closely associated with cellular quiescence, a state whereby cells exit the cell cycle and are …

Quiescence in cancer cells is considered a therapeutic challenge as it confers dormancy in
tumour, hence circumventing inherent anti-neoplastic surveillance system and standard-of …

The TP53 gene is arguably the most important tumor suppressor gene known, contributing
multifaceted roles to the process of tumor development. Its protein product p53, is a crucial …

Cancer is a threat to human health and life. Although previously centered on chemical drug
treatments, cancer treatment has entered an era of precision targeted therapy. Targeted …

Locally advanced non-small cell lung cancer (NSCLC) is frequent at diagnosis and requires
multimodal treatment approaches. Neoadjuvant chemotherapy (NACT) followed by surgery …

There is limited guidance on exploiting the genome‐wide loss‐of‐function CRISPR screens
in cancer Dependency Map (DepMap) to identify new targets for individual cancer types …

Toll-like receptors (TLRs) are evolutionarily conserved molecules that detect exogenous and
endogenous molecular patterns and trigger both the innate and adaptive immune systems to …