Therapeutic Potential of Moringa oleifera Leaves in Chronic Hyperglycemia and Dyslipidemia: A Review
M Mbikay - Frontiers in pharmacology, 2012 - frontiersin.org
Moringa oleifera (M. oleifera) is an angiosperm plant, native of the Indian subcontinent,
where its various parts have been utilized throughout history as food and medicine. It is now …
where its various parts have been utilized throughout history as food and medicine. It is now …
Animal models of neuropathic pain
Animal models are pivotal for understanding the mechanism of neuropathic pain and
development of effective therapy for its optimal management. A battery of neuropathic pain …
development of effective therapy for its optimal management. A battery of neuropathic pain …
[PDF][PDF] Pancreatic (B-Cells of GK Rats, a Model of Type 2 Diabetes
Y Ihara, S Toyokuni, K Uchida, H Odaka, T Tanaka… - Diabetes, 1999 - academia.edu
RESEARCH DESIGN AND METHODS Animals. Male GK rats were maintained in the
Takeda Pharmaceutical Research Laboratories (Osaka, Japan). The study sample included …
Takeda Pharmaceutical Research Laboratories (Osaka, Japan). The study sample included …
IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
JA Ehses, G Lacraz, MH Giroix… - Proceedings of the …, 2009 - National Acad Sciences
Recent studies suggest an inflammatory process, characterized by local cytokine/chemokine
production and immune cell infiltration, regulates islet dysfunction and insulin resistance in …
production and immune cell infiltration, regulates islet dysfunction and insulin resistance in …
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
NIDDM is a polygenic disease characterized by insulin resistance in muscle, fat, and liver,
followed by a failure of pancreatic β cells to adequately compensate for this resistance …
followed by a failure of pancreatic β cells to adequately compensate for this resistance …
A review of rodent models of type 2 diabetic skeletal fragility
RJ Fajardo, L Karim, VI Calley… - Journal of Bone and …, 2014 - academic.oup.com
Evidence indicating that adult type 2 diabetes (T2D) is associated with increased fracture
risk continues to mount. Unlike osteoporosis, diabetic fractures are associated with obesity …
risk continues to mount. Unlike osteoporosis, diabetic fractures are associated with obesity …
Diabetic neuropathy–a continuing enigma
K Sugimoto, Y Murakawa… - … /metabolism research and …, 2000 - Wiley Online Library
In this article we will review the clinical signs and symptoms of diabetic somatic
polyneuropathy (DPN), its prevalence and clinical management. Staging and classification …
polyneuropathy (DPN), its prevalence and clinical management. Staging and classification …
Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat
J Galli, LS Li, A Glaser, CG Östenson, H Jiao… - Nature …, 1996 - nature.com
Non-insulin dependent diabetes mellitus (NIDDM) is a major public health problem, but its
aetiology remains poorly understood. We have performed a comprehensive study of the …
aetiology remains poorly understood. We have performed a comprehensive study of the …
Impaired development of pancreatic beta-cell mass is a primary event during the progression to diabetes in the GK rat
J Movassat, C Saulnier, P Serradas, B Portha - Diabetologia, 1997 - Springer
In the endocrine pancreas of the GK rat, a genetic model of non-insulin-dependent diabetes
mellitus (NIDDM), it is not clear whether the histopathological changes reported up to now …
mellitus (NIDDM), it is not clear whether the histopathological changes reported up to now …
Programmed disorders of β‐cell development and function as one cause for type 2 diabetes? The GK rat paradigm
B Portha - Diabetes/metabolism research and reviews, 2005 - Wiley Online Library
Now that the reduction in β‐mass has been clearly established in humans with type 2
diabetes mellitus (T2DM) 1–4, the debate focuses on the possible mechanisms responsible …
diabetes mellitus (T2DM) 1–4, the debate focuses on the possible mechanisms responsible …