[HTML][HTML] Confronting racism in all forms of pain research: reframing study designs

JE Letzen, VA Mathur, MR Janevic, MD Burton… - The journal of pain, 2022 - Elsevier
This second paper in a 3-part series on antiracism in pain research across the translational
spectrum focuses on study design factors. Although objectivity is a cornerstone value of …

Sickle cell trait and the potential risk of severe coronavirus disease 2019—A mini‐review

TA Kehinde, MA Osundiji - European Journal of Haematology, 2020 - Wiley Online Library
Abstract Coronavirus Disease 2019 (COVID‐19) pandemic is a rapidly evolving public
health problem. The severity of COVID‐19 cases reported hitherto has varied greatly from …

Transferability of real-world data across borders for regulatory and health technology assessment decision-making

A Jaksa, PJ Arena, KKW Chan, RH Ben-Joseph… - Frontiers in …, 2022 - frontiersin.org
Recently, there has been increased consideration of real-world data (RWD) and real-world
evidence (RWE) in regulatory and health technology assessment (HTA) decision-making …

The value-based price of transformative gene therapy for sickle cell disease: a modeling analysis

G Morgan, E Back, M Besser, TB Hallett… - Scientific Reports, 2024 - nature.com
Sickle cell disease (SCD) is an inherited, progressively debilitating blood disorder.
Emerging gene therapies (GTx) may lead to a complete remission, the benefits of such can …

Deep learning detection of sea fan neovascularization from ultra-widefield color fundus photographs of patients with sickle cell hemoglobinopathy

S Cai, F Parker, MG Urias, MF Goldberg… - JAMA …, 2021 - jamanetwork.com
Importance Adherence to screening for vision-threatening proliferative sickle cell retinopathy
is limited among patients with sickle cell hemoglobinopathy despite guidelines …

Racial and ethnic differences in sickle cell disease within the United States: From demographics to outcomes

A Pokhrel, A Olayemi, S Ogbonda… - European Journal of …, 2023 - Wiley Online Library
Introduction Sickle cell disease mainly affects African Americans, and studies on racial
differences in sickle cell disease outcomes are scanty. This study examined racial and …

End Organ Affection in Sickle Cell Disease

T Bathla, S Lotfollahzadeh, M Quisel, M Mehta… - Cells, 2024 - mdpi.com
Sickle cell disease is an orphan disease affecting ethnic minorities and characterized by
profound systemic manifestations. Although around 100,000 individuals with SCD are living …

Role of Clinical Pharmacology in Diversity and Inclusion in Global Drug Development: Current Practices and Industry Perspectives: White Paper

A Sawant‐Basak, S Urva, JK Mukker… - Clinical …, 2024 - Wiley Online Library
The 2022 United States Food and Drug Administration (US FDA) draft guidance on diversity
plan (DP), which will be implemented through the Diversity Action Plans by December 2025 …

Low‐value care in pediatric populations: There is no silver lining.

CK Gutman, S Holmes, KS Balhara… - Academic Emergency …, 2022 - search.ebscohost.com
The article reports that cross-sectional analysis of 4.6 million children discharged from 45
US pediatric emergency departments and find higher odds of lowvalue care delivery for non …

Distribution of HbS Allele and haplotypes in a multi-ethnic population of Guinea Bissau, West Africa: Implications for public health screening

M Martella, M Campeggio, G Pulè, A Wonkam… - Frontiers in …, 2022 - frontiersin.org
Background Sickle Cell Disease (SCD) is an inherited condition that is widespread globally
and especially in malaria-endemic West African countries. Limited epidemiological data on …