The spectrum of ischaemic cardiomyopathy, encompassing acute myocardial infarction to
congestive heart failure is a significant clinical issue in the modern era. This group of …

As part of the TACTICS (Transnational Alliance for Regenerative Therapies in
Cardiovascular Syndromes) series to enhance regenerative medicine, here, we discuss the …

Cell therapy is a promising strategy to regenerate cardiac tissue for myocardial infarction.
Injectable hydrogels with conductivity and self-healing ability are highly desirable as cell …

Context Mesenchymal stem cells (MSCs) are under evaluation as a therapy for ischemic
cardiomyopathy (ICM). Both autologous and allogeneic MSC therapies are possible; …

Development of localized inflammatory environments by M1 macrophages in the cardiac
infarction region exacerbates heart failure after myocardial infarction (MI). Therefore, the …

The mammalian heart has a very limited regenerative capacity and, hence, heals by scar
formation. Recent reports suggest that haematopoietic stem cells can transdifferentiate into …

Under conditions of tissue injury, myocardial replication and regeneration have been
reported. A growing number of investigators have implicated adult bone marrow (BM) in this …

Abstract Aims Mesenchymal stem cells (MSCs), rare bone marrow-derived stem cell
precursors of non-haematopoietic tissues, have shown promise in potentially repairing …

In this study, we hypothesized that bone marrow stem cells (BMSCs) protect ischemic
myocardium through paracrine effects that can be further augmented with preconditioning. In …

The aim of this study was to determine whether intravenously administered multipotent
stromal cells from human bone marrow (hMSCs) can improve cardiac function after …