Copper microenvironments in the human body define patterns of copper adaptation in pathogenic bacteria

F Focarelli, A Giachino, KJ Waldron - PLoS pathogens, 2022 - journals.plos.org
Copper is an essential micronutrient for most organisms that is required as a cofactor for
crucial copper-dependent enzymes encoded by both prokaryotes and eukaryotes. Evidence …

[HTML][HTML] Deadly excess copper

J Sailer, J Nagel, B Akdogan, AT Jauch, J Engler… - Redox biology, 2024 - Elsevier
Higher eukaryotes' life is impossible without copper redox activity and, literally, every breath
we take biochemically demonstrates this. However, this dependence comes at a …

Peptide-based probe for colorimetric and fluorescent detection of Cu2+ and S2-in environmental and biological systems

Y An, L Li, L Li, Y Sun, B Li, P Wang - Journal of Hazardous Materials, 2024 - Elsevier
Pollution caused by Copper and hydrogen sulfide pollution has severe adverse effects on
the environment and organisms. Real-time, fast and accurate monitoring of Cu 2+ and S 2 …

Copper and diabetes: current research and prospect

W Chang, P Li - Molecular Nutrition & Food Research, 2023 - Wiley Online Library
Copper is an essential trace metal for normal cellular functions; a lack of copper is reported
to impair the function of important copper‐binding enzymes, while excess copper could lead …

Protein-templated ligand discovery via the selection of DNA-encoded dynamic libraries

Y Zhou, W Shen, Y Gao, J Peng, Q Li, X Wei, S Liu… - Nature Chemistry, 2024 - nature.com
DNA-encoded chemical libraries (DELs) have become a powerful technology platform in
drug discovery. Dual-pharmacophore DELs display two sets of small molecules at the …

Biosynthesis of copper nanoparticles with medicinal plants extracts: from extraction methods to applications

A Antonio-Pérez, LF Durán-Armenta, MG Pérez-Loredo… - Micromachines, 2023 - mdpi.com
Copper nanoparticles (CuNPs) can be synthesized by green methods using plant extracts.
These methods are more environmentally friendly and offer improved properties of the …

Copper-instigated modulatory cell mortality mechanisms and progress in oncological treatment investigations

L Gao, A Zhang - Frontiers in Immunology, 2023 - frontiersin.org
Copper, a transition metal, serves as an essential co-factor in numerous enzymatic active
sites and constitutes a vital trace element in the human body, participating in crucial life …

Targeted modulation and enhancement of macrophages via sonodynamic therapy-driven cupferroptosis-like stress for implant-associated biofilm infections

X Zhang, Z Wang, Q Liu, X Hu, J Mei, D Xu, J Zhou… - Nano Today, 2024 - Elsevier
As the vanguard against implant-associated infections (IAIs), macrophages facilitate the
phagocytosis and pro-inflammatory polarization of planktonic and biofilm infections, but …

Copper toxicity and deficiency: the vicious cycle at the core of protein aggregation in ALS

JH Min, H Sarlus, RA Harris - Frontiers in Molecular Neuroscience, 2024 - frontiersin.org
The pathophysiology of ALS involves many signs of a disruption in copper homeostasis, with
both excess free levels and functional deficiency likely occurring simultaneously. This is …

Comparative genomics of the proteostasis network in extreme acidophiles

K Izquierdo-Fiallo, C Muñoz-Villagrán, O Orellana… - Plos one, 2023 - journals.plos.org
Extreme acidophiles thrive in harsh environments characterized by acidic pH, high
concentrations of dissolved metals and high osmolarity. Most of these microorganisms are …